文档介绍：中国组织工程研究第 16 卷第 2 期 2012– 01– 08 出版
Chinese Journal of Tissue Engineering Research January 8, 2012 ,
腺苷 A2A受体基因敲除小鼠瘢痕胶原亚型的变化** ☆
肖虎,李少华,王德昌,霍然,王一兵,冯永强,李强
Detection of collagens in hypertrophic scars of adenosine receptor A2A knockout mice by
picrosirius polarization method
Xiao Hu, Li Shao-hua, Wang De-chang, Huo Ran, Wang Yi-bing, Feng Yong-qiang, Li Qiang
Abstract
BACKGROUND: Recent study shows that the adenosine receptor agonists can promote the collagen synthesis, and the Department of Burns
and Plastic Surgery,
adenosine receptor antagonists can inhibit the collagen synthesis and reduce the proliferation of skin collagen fiber. The Provincial Hospital
expression of transforming growth factor β(TGF-β) in hypertrophic scar of adenosine A2A knockout mice models is decreased. Affiliated to
OBJECTIVE: To observe the changes of collagens in hypertrophic scars of adenosine receptor A2A knockout mice and its Shandong University,
mechanism by picric acid-sirius red polarization method. Jinan 250021,
Shandong Province,
METHODS: The models of hypertrophic scars were made by adenosine A2A knockout mice and wild-type mice. The character China
and the distribution of the collagen in the hypertrophic scars were observed by picric acid-sirius red polarization method, and the
type of the collagen, distribution, arrangement and content was c