文档介绍：中国药房 2014年第25卷第12期 China Pharmacy 2014 Vol. 25 No. 12西酞普兰联合养血清脑颗粒治疗脑卒中后抑郁的临床观察周勇*,龙明,冉宏(重庆三峡医药高等专科学校附属医院,重庆万州 404000)中图分类号 文献标志码 A 文章编号 1001-0408(2014)12-1105-03DOI .1001-:观察西酞普兰联合养血清脑颗粒治疗脑卒中后抑郁的疗效和安全性。方法:选取120例确诊为脑卒中后抑郁的患者,按照随机数字表法均分为4组。对照组患者采用常规治疗;观察一组患者在对照组治疗基础上加服西酞普兰;观察二组患者在对照组治疗基础上加服养血清脑颗粒;观察三组在对照组治疗基础上加服西酞普兰和养血清脑颗粒。4组患者疗程均为6周。观察治疗前和治疗2、4、6周后患者的汉密尔顿抑郁量表(HAMD)和副反应量表(TESS)评分,评定疗效和安全性。结果:治疗6周后,观察一组、观察二组、%、%、%,%,观察三组最高,对照组最低,分别与其他3组比较差异均有统计学意义(P<),而观察一组与观察二组差异无统计学意义(P>)。治疗前4组HAMD评分比较差异无统计学意义(P>);观察一组、观察二组、观察三组治疗2、4、6周后HAMD评分均较治疗前显著降低,且治疗6周后观察三组的HAMD评分最低,与其他组比较差异有统计学意义(P<)。4组的不良反应症状均较轻,发生率比较差异无统计学意义(P>)。结论:西酞普兰联合养血清脑颗粒治疗脑卒中后抑郁的疗效显著,且安全性较高。关键词西酞普兰;养血清脑颗粒;脑卒中;抑郁Clinical Observation of bined with Yangxue Qingnao Particle in the Treatment of Post-stroke DepressionZHOU Yong,LONG Ming,RAN Hong(The Affiliated Hospital of Chongqing Three Gorges Medical College,Chongqing Wanzhou 404000,China)ABSTRACT OBJECTIVE:To observe the therapeutic efficacy and safety of bined with Yangxue qingnao particlein the treatment of post-stroke depression. METHODS:120 patients diagnosed as post-stroke depression in our hospital were ran-domly divided into 4 groups with 30 cases in each group. Control group received conventional treatment;observation group 1 wasadditionally given citalopram,observation group 2 Yangxu