文档介绍：叶酸对冠心病患者血管内皮功能的影响
【摘要】探讨大剂量叶酸能否改善冠心病患者的血管内皮功能。方法共60例冠心病患者分为叶酸治疗(20 mg/d)组30例和对照组30例,随访6个月,观察2组间同型半胱氨酸水平,以超声测定肱动脉血流介导的内皮依赖性舒张变化率(FMD)变化来评价血管内皮功能,并观察2组间差别。结果大剂量叶酸治疗组血浆同型半胱氨酸水平低于对照组〔(±) μmol/L vs. (±) μmol/L,P<〕。%±%%±%(P<)。结论大剂量叶酸治疗可能通过降低同型半胱氨酸以外的途径改善血管内皮功能,对冠心病患者有潜在的益处。
【关键词】冠状动脉疾病内皮血管叶酸
Abstract: Objective To decide whether big-dose folic acid supplementation can improve endothelial function in patients with coronary artery disease. Methods Sixty patients with coronary artery disease were divided into two groups: 30 were put on folic acid supplement (20 mg/d) for 6 months, the other 30 were taken as controls. The plasma homocystine (Hcy) was determined by fluorescence polarization immunoassay; the flow-mediated endothelium-dependent dilation (FMD) of the brachial artery was assessed by high resolution ultrasound before and after the test. pared with the control, folic acid therapy resulted in lowering of plasma Hcy level
[(±) μmol/L vs. (±) μmol/L, P<] and significant improvement in FMD [%±% vs. %±%, P<]. Conclusion Big-dose folic acid supplementation may exert beneficial effects on patients with coronary artery disease through certain form of amelioration of vascular endothelial function besides plasma Hcy lowering.
Key words: coronary artery disease; endothelium, vascular; f