文档介绍：慢性心功能不全患者血清甲状腺激素的变化及其临床意义
作者:胡光振万继峰吴保鑫梁艳东李传新
【摘要】目的观察慢性心功能不全( CHF ) 患者血清甲状腺激素的变化,评估其临床意义。方法应用放射免疫法测定33例慢性心功能不全患者血清三碘甲腺原氨酸(T3)、甲状腺素(T4)、反三碘甲腺原氨酸(rT3)和促甲状腺激素(TSH),与11例正常人血清甲状腺激素水平进行对照分析。结果慢性心功能不全患者血清T3明显低于对照组(P<),而血清rT3高于对照组(P<<)。血清 T4和TSH与对照组相比差异无显著性(P>)。结论慢性心功能不全患者血清T3下降、rT3升高,且与病情相关。其可作为诊断CHF指标,并可用于判断病情。
【关键词】慢性心功能不全;甲状腺激素;放射免疫测定法
Abstract: Objective To investigate the changes of serum thyroid hormone in patients with chronic heart failure (CHF) and to define their clinical significances. Methods Radioimmunoassay was applied to determine the serum levels of T3, T4, rT3 and TSH in 33 CHF patients and 11 normal subjects. Results The T3 level was lower in CHF group than in the control (P<), but the level of rT3 was higher (P< or ). No differences in T4 and TSH levels were found between the CHF patients and the normal subjects. Conclusion T3 decreases and rT3 increases in the patients with CHF. They two are correlated with the
degree of the heart failure, serving as the diagnostic index of CHF.
Key words: chronic heart failure; thyroid hormone; radioimmunoassay
慢性心功能不全( CHF )患者由于神经内分泌激素的调节会出现一系列内分泌激素变化,而血清甲状腺激素变化可直接影响患者心肌收缩力改变,从而影响心力衰竭(心衰)治疗,故观察分析CHF患者血清甲状腺激素变化意义较大。我们观察分析了33例CHF患者血清甲状腺激素变化情况并探讨了其临床意义,现报道如下。
1 资料和方法
一般资料对象为我院内科近1年来治疗的CHF患者33例(CHF组),均符合WHO制定的CHF诊断标准,其心功能按NYHA分级。本组中男12例、女21例,年龄19~71岁,平均(±)岁;按心功能分级,其中Ⅱ级8例,Ⅲ级