文档介绍：热盐水致大鼠萎缩性胃炎胃黏膜超微结构的变化
作者:张沥,王春梅,陶梅,张玲霞,江梅,曹广周
【关键词】萎缩性胃炎
【Abstract】 AIM: To observe the ultrastructure diversification of gastric mucosa in atrophic gastritis rat model caused by highsalthot water and to study the pathogenesis of atrophic gastritis caused by highsalthot diet. METHODS: The atrophic gastritis rat model was made by highsalthot water(55℃,150 g/mL, mL/d, for 32 weeks)perfusion and the ultrastructure of gastric mucosa was observed by transmission electromicroscope. RESULTS: In the early stage of highsalthot water perfusion, the swell of mitochondrion, dilation of rough endoplasmic reticulum and short or lost of microvillus were observed in gastric mucosa. With the passage of time, the structure of mitochondrion became blurring, the endoplasmic reticulum dilated notably and microvillus lost significantly. CONCLUSION: Highsalthot water perfusion may cause ultrastructural damage in gastric mucosa.
【Keywords】 highsalthot water;atrophic gastritis;u
ltrastructure
【摘要】目的:研究热盐水灌胃导致的大鼠萎缩性胃炎(CAG)胃黏膜组织细胞超微结构的改变. 方法:用热盐水灌胃(55℃,150 g/L, mL/d×32 wk)建立大鼠萎缩性胃炎动物模型,选取大鼠腺胃胃窦组织行透射电镜标本制备并对组织细胞超微结构的变化进行动态观察. 结果:电镜观察到热盐水灌胃较早就出现了线粒体肿胀,粗面内质网扩张,微绒毛变短或丢失,随灌胃时间的延长,线粒体肿胀明显,局部空泡化,部分线粒体溶解坏死. 内质网扩张明显,部分脱颗粒,微绒毛大量丢失. 结论:热盐水灌胃可引起胃黏膜组织细胞超微结构的损害.
【关键词】热盐水;萎缩性胃炎;超微结构
0引言
慢性萎缩性胃炎(chronic atrophic gastritis)癌变率约2%~8%. 长期高盐饮食可导致慢性萎缩性胃炎,甚至诱发癌变[1]. 动物实验也已证实过热过咸的饮食可造成萎缩性胃炎[2,3].