文档介绍：新疆医科大学
硕士学位论文
帕金森病嗅觉障碍的相关性研究
姓名:樊毅
申请学位级别:硕士
专业:神经病学
指导教师:杨新玲
2011-04
新疆医科大学硕士学位论文
帕金森病嗅觉障碍的相关性研究
研究生:樊毅导师:杨新玲教授
摘要
目的:研究原发性帕金森病患者嗅觉功能改变情况,探讨其与病程、病情和年
龄的关系以及可能对帕金森病早期诊断的价值。方法:选用确诊的原发性帕金森病
患者 41 例,其中男性 23 例,女性 18 例,年龄(44-80)岁,平均(61±)岁;
病程(3 月-13 年),平均(4±)年,所有病例均符合 2006 年中华医学会神经病
学分会运动障碍及帕金森病学组制定的帕金森病诊断标准;选择年龄、民族、性别
相匹配、文化程度近似匹配同期来本院的健康体检者和住院患者健康家属 41 例作为
对照组,男 23 例,女 18 例,年龄(44-80)岁,平均(61±)岁。两组均为汉
族。对所有入选对象进行简明精神状态量表(MMSE)和简易嗅觉测定,观察嗅觉
功能改变情况及其与病情、年龄、病程的关系。结果:病例组嗅觉障碍的发生率为
%,显著高于健康对照组的 %(P <);在病情与嗅觉障碍发生率的比较
显示:轻度 PD 组和中重度 PD 组间差异有统计学意义(P <);考虑年龄因素的
影响:在发病年龄≥60 岁分组中:两亚组间差异有统计学意义(P <)。嗅觉障
碍发生率:中重度 PD 组比轻度 PD 组高;病例组嗅觉障碍发生率与年龄、病程的比
较,差异无统计学意义(P >)。结论:帕金森病患者存在嗅觉功能异常,其与
病程、年龄无相关性,与病情相关。嗅觉检测对帕金森病的早期诊断具有一定的应
用价值。
关键词:帕金森病;嗅觉障碍;简易嗅觉检测
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新疆医科大学硕士学位论文
Correlative Study on Olfactory Dysfunction of Patients
with Parkinson’s Disease
Postgraduate:FAN Yi Supervisor: Prof. Yang Xinling
Abstract
Objective: To study olfactory function in chinese patients with parkinson’s disease
and to explore the relationship of these changes among its course, its condition, its onset
age and the possibility of early diagnosis of Parkinson's disease.
Methods:41cases of diagnosed parkinson’s disease were chosed ,Among the 41 patients,
23 male and 18 range from 44 to 80 years age is 61± years
old..Disease course range from 3 months to 13 course is 4± years。all cases
were accord with the diagnostic criteria of PD refered to the neurology branch, dyskinesia
and parkinson’s disease group of Chinese Medical Association( 2006).41 cases of healthy
families of hospitalised patients and healthy subjects severed as normal controls were
chosed ,whose age,nationality and gender-matched and cultural degree approximate
male and 18 range from 44 to 80 years groups were the
Han nationality. 41 PD p