文档介绍：中华临床医师杂志(电子版)2011 年 12 月第 5 卷第 24 期( ), 15,2011, .5, .24 ·1627·
Chin J Clinicians Electronic Edition December Vol No
· 论著·
柯尔莫哥罗夫熵对大鼠痫性发作的预报价值
王顺先马英王寅旭
【摘要】目的研究柯尔莫哥罗夫熵( )在氯化锂唱匹鲁卡品致痫大鼠脑电监测中的应用,探
KE
讨运用预报痫性发作的可行性。方法将 24 只健康雄性大鼠随机分为 3 组,分别为正常组、
KE SD
对照组和致痫组,致痫组采用氯化锂唱匹鲁卡品制作急性痫性发作模型,利用头皮电极连续记录大鼠
脑电信号,运用对痫性发作大鼠全过程的脑电信号进行分析,并与正常组及注射生理盐水的对照
KE
组对比分析。结果在整个痫性发作过程中, 在发作前期开始下降,而在痫性发作期显著下降,与
KE
发作间期比较,发作前期与发作期的明显降低。致痫组痫性发作期和发作前期的值与正常组
KE KE
对比差异具有统计学意义(P <0畅05)。结论的变化提示痫性发作过程脑电信号复杂度的变化
KE
过程,并为痫性发作的预报提供了可能。
【关键词】癫痫; 脑电描记术; 柯尔莫哥罗夫熵
Value of Kolmogorov entropy on the prediction of seizure in epileptic rats WANG Shun唱xian,MA
Ying,WANG of Neurology,Affiliated Hospital of North Sichuan Medical College,Nanchong
637000,China
Corresponding author:MA Ying,Email:yingma1314@
【Abstract】 Objective ( )
To investigate the application of Kolmogorov entropy KE in epileptic rats
唱, .Methods 唱
induced by lithium pilocarpine and to explore its value in predicting epileptic seizures Twenty
唱( ) 3 : ,
four Sprague Dawley SD rats were randomly divided into groups a normal group a control group and
. 唱.
epileptic group Acute chemical models were made by lithium pilocarpine The rats were received continuous
( ) .
electroencephalographic EEG monitoring by scalp surface electrode Changes of KE of EEG signal in the
epileptic group were analysis in th