文档介绍：2型糖尿病患者心率变异性与尿白蛋白排泄率的关系
(作者:___________单位: ___________邮编: ___________)
作者:陈越潘文志钟一红丁小强
【摘要】目的探讨2型糖尿病患者心率变异性(HRV)与尿白蛋白排泄率(UAER)的相关性。方法将90例2型糖尿病患者按照UARE不同分为糖尿病正常白蛋白尿组(N组,51例),糖尿病微量白蛋白尿组(Mi组,25例),糖尿病大量白蛋白尿组(Ma组,14例),并且选取正常健康人30例作为对照组(C组,30例),用24h动态心电图分析其HRV,检测其自主神经功能。结果(1)糖尿病各组的全程内相邻正常窦性心率R-R间期的标准差(SDNN)、全程内每5minR-R间期均值的标准差(SDANN)明显低于正常对照组,且Mi组显著低于N组,Ma组明显低于Mi组()。(2)N组和Mi组的全程内每5minR-R间期标准差的平均值(SDNNI)、相邻正常R-R间期差值的均方根(rMSSD)、相邻正常R-R间期相差50ms的个数占总心跳次数的百分比(PNN50)与C组相比无显著差别,但Ma组较C组显著降低()。结论糖尿病患者随着尿白蛋白排泄率增加,自主神经损害加重。
【关键词】 2型糖尿病心率变异性尿白蛋白排泄率
【Abstract】 Objective To investigate the relationship between HRV and UAER in patients with type 2 diabetes. Methods According to different UAERs, 90 patients with type 2 diabetes are divided into three groups , including normal UAER(group N,51),microalbuminuria(group Mi,25) and macroalbuminuria(group Ma,14),while 30 healthy adults are selected as control group(group C,30). The function of autonomic nerve is tested by 24-hour electrocardiogram analysis of HRV. Results (1)SDNN、SDANN in group N、Mi、Ma decreased more significantly than in control group, and those in group Mi were significantly lower than in group N, the differences were statistically significant().But the difference of SDNN、SDANN in group Mi and group Ma had no statistical significance().(2)There is no difference about SDNNI、rMSSD、PNN50 between group N、Mi and grou