文档介绍：食品与药品 Food and Drug 2008 年第 10 卷第 09 期 3 7
磷酸川芎嗪与盐酸川芎嗪对大鼠局灶性脑缺血模型的作用比较
曹艳花,刘珊珊
(山东大学附属省立医院,山东济南 250022)
摘要:目的比较磷酸川芎嗪和盐酸川芎嗪治疗阻断大鼠大脑中动脉所致大脑局灶性脑缺血模型的疗效。方法
随机将大鼠 4 0 只分为伪模型组、模型对照组、磷酸川芎嗪组、盐酸川芎嗪组。用线栓法阻断大鼠大脑中动脉制备
局灶性脑缺血模型,手术后分别按 1 0 mL/ k g 静脉给药,1 2 h 后对其神经症状评分,2 4 h 后处死动物取脑, TTC
染色, 计算梗死面积,并行病理组织学检测。结果磷酸川芎嗪和盐酸川芎嗪均可明显降低模型大鼠大脑梗死面积
和梗死率,明显减轻模型大鼠的神经症状, 抑制神经元变性坏死和神经细胞水肿等病理组织学改变;与对照组的差
异有统计学意义, 但 2 种药物比较无统计学差异。结论用磷酸川芎嗪和盐酸川芎嗪治疗脑梗死基本等效。
关键词:磷酸川芎嗪; 盐酸川芎嗪; 局灶性脑缺血
中图分类号:R743. 31 文献标识码:A 文章编号:1672- 979X( 2008) 09- 0037 - 03
Compar at i ve St udy on Eff ect of Li gust r azi ne Phosphat e and Li gust r azi ne Hydrochl ori de on
Focal Cer ebr al Ischemi c Rat s
CAO Yan- hua,LI U Shan- shan
( Provi nci al Hospi tal Aff il i at ed to Shandong Universi ty, Ji nan 250022, China)
Abst r act:Obj ect i ve pare the curati ve eff ect of li gustr azi ne phosphat e and l igustr azi ne hydrochl or ide on
f ocal cerebral ischemi a induced by mi ddl e cerebral ar t er y occl usi on i n rat s. Met hods For ty Spr ague- dawl eyr ats
were r andomly divi ded into f our groups: normal cont rol group, model cont rol gr oup, li gustr azi ne phosphat e gr oup
and l igust r azine hydr ochl or i de gr oup. The focal cerebral i schemi c model was i nduced by mi ddl e cer ebr al ar t er y
occl usionwit h intr al uminal t hr eadmethod in r at s. Af ter surger y, the rats wer e t reat ed wit hdif fe