文档介绍：D二聚体检测在深静脉血栓诊断中的临床价值
(作者:___________单位: ___________邮编: ___________)
【摘要】深静脉血栓是中风后恢复期的发病率和死亡率的主要原因之一。此研究主要是调查中风恢复期病人血浆D二聚体检测对于诊断深静脉血栓的特异性、阴性预测值以及经济性。[方法]用D二聚体浊度法分析109例因近期局部出血或缺血导致的中风后长期卧床恢复期患者血浆样本。病人在24小时内血管彩色多普勒超声检查。[结果]血管彩色多普勒超声检查有5例患者有深静脉血栓形成。以500ug/L作为D二聚体的cutoff值分类患者是否有深静脉血栓形成的敏感性100%,特异性89%,阳性预报值31%,阴性预报值100%。[结论]血浆D二聚体含量测定在排除诊断深静脉血栓形成中有非常好的有效性以及可接受的特异性。
【关键词】中风康复;深静脉血栓;D二聚体检测
Abstract: [Objective] Venous thromboembolism is a leading cause of morbidity and mortality during the acute recovery period after stroke. This study investigated the utility of plasma Ddimer level as a diagnostic test for deep vein thrombosis (DVT) in patients hospitalized for stroke rehabilitation. [Methods]Plasma samples were drawn from 109 nonambu
latory rehabilitation patients with recent ischemic or hemorrhagic stroke and assayed for Ddimer with DDimer PLUS method. Samples were drawn within 24 hours of venous duplex ultrasound (VDU) screening for DVT. [Results]Five of 105 patients had DVT identified by VDU scan. The optimal cut point for predicting DVT was Ddimer 500ug/L, resulting in 100% sensitivity, 89% specificity, 31% positive predictive value, and 100% negative predictive value. [Conclusion]Plasma Ddimer level is a simple and inexpensive screening test for DVT during stroke rehabilitation.
Key words: rehabilitation;venous thrombosis; Ddimer
深静脉血栓形成是急性中风后常见而又严重的并发症,是