文档介绍：E-cadherin和β-catenin蛋白的表达与胃黏膜肠上皮化生及胃癌的关系
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作者:郑瑶张建平刘凤军杨京彦王琳
【摘要】目的:探讨E-cadherin和β-catenin蛋白的表达与胃黏膜肠上皮化生及胃癌的关系。方法:观察肠上皮化生的胃黏膜形态特点,应用免疫组织化学Envision法分别检测30例单纯肠上皮化生,38例不典型肠上皮化生和55例胃癌组织中E-cadherin和β-catenin蛋白的表达。结果:E-cadherin和β-catenin蛋白在胃癌组织中的减少表达率显著高于单纯肠上皮化生组织(),而与不典型肠上皮化生组织比较差异无统计学意义()。结论: E-cadherin和β-catenin蛋白参与了胃黏膜从肠上皮化生到胃癌的转化过程,不典型肠上皮化生与胃癌关系密切,属于癌前病变范畴。
【关键词】肠上皮化生·胃肿瘤·钙粘着糖蛋白类·β连环素
【ABSTRACT】 Objective: To study the relationship of expressions of E-cadherin and β-catenin proteins and gastric mucosa intestinal metaplasia and gastric carcinoma. Methods: The immunohistochemical Envision method was used to determine the expressions of E-cadherin and
β-catenin in 30 cases of simple intestinal metaplasia (SIM), 38 cases of atypia intestinal metaplasia (AIM) and 55 cases of gastric carcinoma. Results: The reduced expression rates of E-cadherin and β-catenin in gastric carcinoma were significantly higher than that in SIM(), while there were no significant differences between AIM and gastric carcinoma (). Conclusion: E-cadherin and β-catenin proteins take part in the transformation from intestinal metaplasia to car cinoma in gastric mucosa, AIM is a kind of precancerosis of gastric carcinoma.
肠上皮化生(以下简称肠化)是指正常胃黏膜上皮细胞在一定条件下转化为肠型上皮细胞,是胃黏膜的常见病变。1966年,Lauren将胃癌分为肠型和弥漫型2类,并认为肠化与肠型胃癌的发生有关[1]。E-cadherin是存在于正常上皮细胞中的细胞粘