文档介绍：Egr-1在口腔扁平苔藓及口腔鳞状细胞癌中的表达及意义
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作者:刘丽,臧磊,吕晓丹,漆明,韩恩善
【摘要】目的研究Egr-1在口腔扁平苔藓和口腔鳞状细胞癌组织中的表达及意义。方法采用免疫组织化学法检测15例正常口腔黏膜组织、30例口腔扁平苔藓组织及30例口腔鳞状细胞癌组织中Egr-1的表达。结果正常口腔黏膜组、口腔扁平苔藓组及口腔鳞状细胞癌组的Egr-1阳性表达率在上皮细胞中分别为60%、%及20%,%、100%%;三组之间Egr-1表达比较,差异有统计学意义(P<)。结论 Egr-1参与了口腔扁平苔藓的发病及口腔鳞状细胞癌的发生、发展,并可能与口腔扁平苔藓的癌变有关。
【关键词】口腔扁平苔藓;口腔鳞状细胞癌;早期生长反应基因;免疫组织化学
Abstract: Objective To explore the expression and significance of Egr-1 in oral lichen planus (OLP)and oral squamous cell carcinoma ().Methods The expression of Egr-1 in 15 cases with normal oral mucosa tissues,30 cases with OLP tissues and 30 cases with tissues was detected by immunohistochemical The positive expression rate of normal oral mucosa,oral lichen planus and oral squamous cell carcinoma group were 60%,80%,20% respectively in the epithelial cells,and %,100%,% respectively in the lamina propria and interstitial cells; Egr-1 expression showed significant difference among the three groups (P<).Conclusion Egr-1 participated in the pathogenesis of OLP and the occurrence,development of ,and might be playing an important role in carcinogenesis of OLP.
Key words:OLP; ; Egr-1; immunohistochemistry
早期生长反应因子(early growth response gene-1,Egr-1) 为即刻早期基因,是一个含3个锌指结构的转录因子[1-2]。近来研究表明Egr-1参与了许多炎症相关性疾病的发生发展;调控某些决定细胞核型变化的下游长期反应基因的表达,可以促进或抑制细胞增生,其作用取决