文档介绍：Graves病患者甲亢性肝损害及其相关因素分析
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作者:田竹芳,施秉银,赵新,高珊,胡文华
【摘要】目的探讨Graves病(GD)患者甲亢性肝损害的发生率及其相关因素。方法 GD患者280例,分为未治组(131例)和经治组(149例),检测肝功能指标、血清甲状腺激素水平、甲状腺自身抗体。对其肝功能损害的发生率、临床特点及相关因素进行分析。%,%;甲亢性肝功能损害最常见的异常指标是碱性磷酸酶(ALP)增高,未治组、%、%;血清谷丙转氨酶(ALT)%、%;血清谷草转氨酶(AST)%、%;%、%;谷酰胺转肽酶(GGT)%、%;甲亢性肝功能损害的发生与病程、甲状腺疾病家族史、性别、TGAb水平、TMAb水平无关,与年龄、甲状腺激素水平有关。结论 GD患者甲亢性肝损害较常见,肝功能损害最常见的异常指标是ALP、ALT,甲亢性肝功能损害与甲状腺激素水平、年龄有关。
【关键词】 Graves病;肝功能;甲状腺激素;TGAb;TMAb
ABSTRACT: Objective To investigate the incidence and the possible risk factors of hepatic dysfunction in patients with Graves disease (GD). Methods Totally 280 outpatients with hyperthyroidism (caused by GD) were divided in two groups: untreated group (131 patients) and treated group (149 patients). The hepatic function, serum thyroid hormone, TGAb and TMAb were detected for analysis of the incidence, clinical characteristics and correlative factors of the hepatic dysfunction. Results Patients who had at least one abnormal result of liver function test accounted for % in untreated group and % in treated group. The mon abnormal hepatic function parameter in patients with thyrotoxic hepatic lesion was increased alkaline phosphate enzyme (ALP), which was % in untreated group