文档介绍：HIF-1α与CAⅨ在肾细胞癌中的表达及临床意义
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【摘要】目的探讨缺氧诱导因子-1α(HIF-1α)与碳酸酐酶9(CAⅨ)在肾细胞癌中的表达及相互关系。方法采用免疫组织化学P-V方法检测54例肾癌石蜡标本切片中HIF-1α和CAⅨ的表达,并探讨其与临床病理因素之间的关系。结果 HIF-%(30/54),其表达与不同临床分期、病理分级有关() ,与组织学类型无关();CAⅨ%(37/54),其表达与不同临床分期、病理分级及组织学类型无关(P>);HIF-1α和CAⅨ在肾癌组织中的表达呈正相关(r=,P=)。结论肾癌中HIF-1α和CAⅨ的高表达和高相关性提示了以缺氧诱导因子通路为基础的分子靶向治疗的可行性。
【关键词】肾细胞癌;缺氧诱导因子-1α;碳酸酐酶9
Abstract: Objective To investigate the expression of HIF-1α and CAⅨ in renal cell carcinoma (RCC) and to evaluate their significance. Methods The expressions of HIF-1
α and CAⅨ were tested by immunohistochemistry in 54 specimens of RCC tissue, with the results analyzed by relating them to the clinical stage and pathological grade. Results The HIF-1α expression in RCC tissue was %, not related to the histological type (), but related to the clinical stage and pathological grade of RCC () . The CAⅨ expression in RCC tissue was % positive, not related to the histological type, pathological grade or clinical stage of RCC (). The expression of HIF-1α was positively correlated with the expression of CAⅨ(r=, P=). Conclusion The overexpression and high correlation of HIF-1α and CAⅨ in renal cell carcinoma support the feasibility of using targeted molecular therapy to treat RCC.
Key words: renal cell carcinoma