文档介绍：6例高甲胎蛋白慢乙肝患者用干扰素治疗的随访分析
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【摘要】目的了解慢性乙型肝炎AFP升高患者的转归。方法对6例极高AFP患者进行抗病毒治疗,主要用重组人干扰素α1b及护肝治疗。随访(3~7)年。结果 6例慢肝患者的AFP分别为1096 ng/ml,1600 ng/ml,4111 ng/ml,1846 ng/ml,1096 ng/ml,1135 ng/ml。住院及出院随访期间,AFP等实验室指标逐渐降至正常或接近正常。影象学检查未发现肝脏有占位性病变。结论 AFP异常升高提示肝细胞过度增生,有转变为肝细胞癌的危险。干扰素抑制肝细胞过度增生,有阻断转变为肝细胞癌的效果。
【关键词】甲胎蛋白干扰素肝细胞癌
Abstract: Objective To investigate conversion of elevated AFP in patients with chronic hepatitis Antiviral therapy (with human interferon)was mainly used in six patients with markedly high AFP. And it was followed up for three to seven years. Results The levels of AFP and other marks were measured during duration of hospital stay and follow-up. The result shows that the levels decreased gradually to be normal and no space occupying lesion was found with imaging It suggested AFP elevated abnormally was owing to the hyperplasia of hepatocyte cell, and had higher risk of canceration. Using interferon may inhib
it the hyperplasia of hepatocyte and block the canceration.
Keywords:AFP; interferon; hepatocellular carcinoma
慢性乙型肝炎患者甲胎蛋白(AFP)持续升高,有发生肝细胞癌(HCC)的高度危险。AFP超过400ng/ml,影象学肝脏有占位性病变,可确诊肝细胞癌的临床诊断。但是,不论急、慢性肝炎还是重型肝炎,发生AFP升高的现象很常见。即使AFP超过400ng/ml的患者,也不一定发生肝细胞癌。本文对用干扰素治疗的6例极高AFP慢乙肝患者经最长达7年的随访(2000年9月~2007年12月),仍未发生肝细胞癌的病例进行分析。
1 资料与方法
临床资料 2000年-2007年本科收治的 6例慢乙肝患者,男性5例,女性1例。年龄(30~50)岁。临床诊断依