文档介绍：p38蛋白激酶在诱导凋亡前后胃癌组织中的表达及意义
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【摘要】目的探索p38蛋白激酶在胃癌组织中的表达及其意义,以及其在术前诱导化疗中的作用。方法对30例进展期胃癌患者术前进行新辅助化疗2个周期,采用免疫组织化学SP法检测30例未行术前化疗患者(未化疗组)和30例术前行新辅助化疗患者(化疗组)的胃癌组织、癌旁组织标本中p38蛋白激酶的表达情况。结果未化疗组胃癌组织中p38蛋白激酶表达高于癌旁组织;Ⅳ期及Ⅱ、Ⅲ期胃癌组织中p38蛋白激酶表达高于Ⅰ期胃癌组织。化疗组Ⅳ期胃癌组织中p38蛋白激酶表达与Ⅱ~Ⅲ期胃癌组织中的表达差异有显著性()。结论 p38蛋白激酶表达水平与胃癌的分期相关;术前化疗诱导凋亡后胃癌组织中p38蛋白激酶表达下降。p38蛋白激酶表达水平与胃癌的发生、发展和转移密切相关;p38蛋白激酶参与了胃癌细胞的诱导凋亡。
【关键词】 p38蛋白激酶;胃癌;化疗;免疫组织化学
Abstract:Objective To investigate the significance of the expression of p38 mitogen-activated protein kinases (MAPK) in gastric cancer and the role of p38 MAPK in preoperative chemotherapy to induce apoptosis. Methods 60 patients with gastric cancer were randomized into the chemotherapy group and the non-chemotherapy group. In the chemotherapy group, preoperative neoadjuvant chemotherapy was performed for 2 weeks on 30 cases with gastric carcinoma during progressive period. Immunohistochemical SP method was employed to determine the expression of p38 MAPK in the cancer samples and the adjacent tissues in both In the non-chemotherapy group, the p38 expression level in the cancer tissue was higher than that in the adjacent tissues and was significantly higher in gastric cancer of clinical stages
Ⅳ, Ⅱ and Ⅲ than that of stage Ⅰ. In the neoadjuvant chemotherapy cases, the p38 expression level in cancer tissues of stage Ⅳ