文档介绍：癌症化疗中拉米呋啶抗乙肝病毒重激活的作用
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作者:黄唯,王安,陈渝萍,梁华敏,郭婷婷
【摘要】目的观察拉米呋啶对携带乙肝病毒(HBV)癌症患者化疗导致病毒重激活的预防以及对患者肝功能的影响。方法收集2003年1月至2008年1月在本院进行化疗的携带HBV癌症患者89例,随机分为化疗组(n=45)和拉米呋啶组(n=44),检测两组化疗前后谷草转氨酶(AST)、谷丙转氨酶(ALT)、总胆红素、白蛋白(ALB)、血清淀粉酶、HBV标记物和HBV DNA水平,同时进行肿瘤化疗及疗效的常规指标检测。结果治疗前两组的AST、ALT、总胆红素、ALB和HBV DNA水平比较差异均无统计学意义;%的患者出现肝功能异常,%,同时化疗组的AST、ALT和HBV DNA水平明显增高,而总胆红素和ALB无明显变化;毒副反应发生率两组比较差异无统计学意义。结论拉米呋啶可预防HBV感染的癌症患者化疗后病毒的重新激活,且毒副作用较小。
【关键词】 HBV;癌症;化疗;拉米呋啶
Abstract:Objective HBV reactivation mon in hepatitis patients who receive tumor chemotherapy. The objective is to evaluate the use of lamivudine as the primary prophylaxis for HBV reactivation in patients undergoing tumor Eighty nine HBV type hepatitis patients with cancer in Zhuhai City Hospital received tumor chemotherapy according to the standard international guidelines from January, 2003 to January, 2008. Of 89 cases, 44 patients received chemotherapy plus lamivudine (groupⅠ), the left 45 patients received chemotherapy alone (group Ⅱ). The liver function indexes including AST, ALT, total bilirubin, ALB, HBV DNA were checked before and after the treatments. The short term curative effect for chemotherapy was evaluated. Results Before the treatment, no significant difference was observed in the liver function indexes between the two groups. After the treatment,