文档介绍：白介素11治疗急性白血病大剂量化疗后血小板减少的临床观察
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作者:黄燕胡苏胡飞崔文婷李金凤罗萍
【摘要】目的探讨大剂量阿糖胞苷化疗后骨髓抑制期应用重组白介素11的疗效。方法将急性髓系白血病患者随机分成两组:对照组采用大剂量阿糖胞苷化疗,治疗组采用大剂量阿糖胞苷联合重组白介素11治疗。观察外周血血小板的动态变化,包括最低值及恢复时间,观察各组出血情况,计算所需输注血小板的患者比例。结果治疗组疗效优于对照组,治疗组血象恢复较快,血小板最低值较高,出血发生率较低,所需输注血小板的患者比例较低。结论重组白介素11与化疗联合能有效促进血小板生成,从而减轻出血。
【关键词】白血病化学治疗白细胞介素11
【Abstact】 Objective: the purpose of the article is to observate the efficacy of binant human interleukin-11 in bone marrow suppression period after high dose cytarabine chemotherapy. Method: A total of 53 acute myeloid leukemia patients were involved randomly into two groups. The treatment group was treated by high dose cytarabine bined with binant human interleukin-11
,and the controlled group only treated with high dose cytarabine on the dynamic changes of peripheral blood platelets,including the minimum value and recovery time,situation of blooding,and calculation of the required percentage of patients with platelet transfusion. Results: The curative effect in treatment group was superior to the control treatment group had more quickly hemogram recovered,higher platelet minimum value, lower incidence of blooding, and a lower percentage of transfusion of platelets of patients. Conclusion: binant human interleukin-11 bination with chemotherapy can effectively promote platelet production and red