文档介绍：斑蝥黄质抗去势雌性大鼠骨质疏松的实验研究
(作者:___________单位: ___________邮编: ___________)
作者:裴凌鹏李莉尹露董福慧
【摘要】目的探讨斑蝥黄质对去卵巢骨质疏松(OP)模型大鼠股骨的密度、骨矿含量的影响及机制。方法将72只15周龄SD大鼠随机分为6组,空白组行假手术,其余5组行卵巢切除术,术后用药12 w后处死,测定右侧股骨骨密度、骨矿含量、血清雌二醇(E2)、碱性磷酸酶(ALP)含量及子宫湿重。结果与模型组相比,斑蝥黄质高(20 mg/kg)、中(15 mg/kg)、低剂量(10 mg/kg)组和尼尔雌醇组( mg/kg)能缓解因去势后造成的雌鼠骨密度、骨矿含量、血清E2及子宫指数的下降(P<),同时可以抑制血清ALP水平的升高(P<)。结论斑蝥黄质可以改善骨质量,抑制雌性大鼠去卵巢OP的发生,可能具有类似雌激素的效应。
【关键词】骨质疏松;斑蝥黄质;骨密度;雌激素
【Abstract】 Objective To study and analyze the effects of canthaxanthin on osteoporosis of ovariectomized rat models. Methods Seventytwo 15 weeks old SD rats were divided into six groups, including control group and five ovariectomized models. After model groups were fed by different dosages canthaxanthin(10,15,20 mg/kg)for 12 weeks, related indexes, including their length bone mineral density(BMD), bone mineral, serum estradiol, serum alkaline phosphatase(ALP)and uterus index were analyzed. pared with the model group, different dosages groups and nilestriol group had the increased BMD, bone mineral, serum estradiol and uterus index, and the decreased serum ALP (). Conclusions As a female sex hormoneponent, canthaxanthin may ameliorate the bone quality and inhibit osteoporosis of ovariectomized rat models.
【Key words】 Osteoporosis;Canthaxanthin;Bone mineral density;Female sex hormone
绝经后骨质疏松(OP)与卵巢功能衰竭、合成的激素降低有关。斑蝥黄质属一种类胡萝卜素类化合物,研究表明其具有抗氧化、防止