文档介绍：吡格列酮配合生活方式干预对自发性高血压大鼠血压的影响
作者:王威孔俭李杰陈海燕
【摘要】目的评价胰岛素增敏剂吡格列酮(PIO)配合生活方式干预对自发性高血压大鼠(SHR)的降压作用。方法 35只SHR随机分为3组(SHR对照组,PIO用药组及PIO配合生活方式干预组),药物添加到大鼠饮水中,生活方式干预为每日减少投食量并游泳6~15 min,周期为12 w,采用间接方法测量血压。结果 PIO及配合生活方式干预组大鼠饮食控制良好,游泳能力逐渐增强,无意外死亡。PIO有良好的降压效果,药物配合生活方式干预降压效果更佳,体重控制良好。结论 PIO及配合生活方式干预具有良好的降低SHR血压效果,生活方式干预可作为纠正胰岛素抵抗(IR)的方法之一应用到高血压的治疗当中。
【关键词】胰岛素增敏剂;胰岛素抵抗;生活方式;高血压
【Abstract】 Objective To evaluate the effects of insulin sensilizer (Pioglitazone PIO) combining with life style intervention on blood pressure in spontaneously hypertensive rats (SHRs). Methods 35 SHRs were randomly divided into SHR control,PIO (PIO 45 mg/L in drinking water) and bining with life style intervention groups. Decreasing the r
at food and swimming 6~15 min/d acted as life style intervention. Results Rats in bining with life style intervention group had well alimentary control and swimming ability, without accidental death. PIO had satisfactory effects on depressurization. bining with life style intervention had better lowering blood pressure effect and better weight control effect. Conclusions bining with life style intervention has satisfactory effects on depressurization,life style intervention could be a good method for rectifying insulin resistance and curing hypertension.
【Key words】 Insulin sensilizer; Insulin resistance; Life style; Hypertension
高血压病机尚未彻底阐明,主要是由遗传与环境及生活方式多种危险因素交互作用而成的一种全身性