文档介绍：鼻咽癌同步加量调强放射治疗的剂量学研究
作者:辛勇,章龙珍,周凤娟,徐玉梅
【摘要】目的比较同步加量调强放射治疗(SMART)计划与常规适形放疗(CRT)计划应用于鼻咽癌放疗的剂量学特点。方法选择23例鼻咽癌患者,分别用SMART束流调强放疗(SMART)计划(SMART组)和常规放疗(CRT)计划(CRT组)进行计划设计。用剂量体积直方图(DVH)分别评价2组靶区、腮腺、周围正常组织受量情况。结果 SMART组各靶区的受量与适形度均高于CRT组(P<),而腮腺等正常组织受量明显低于CRT组(P<)。结论 SMART 调强适形放疗能有效减少患者的周围正常组织受量,提高靶区的适形度和平均剂量。
【关键词】鼻咽癌;同步加量束流调强放射治疗
Abstract: Objective pare the dosimetric characteristics of simultaneous modulated accelerated radiotherapy (SMART) and conventional conformal radiotherapy (CRT) in the radiotherapy of nasopharyngeal carcinoma (NPC). Methods 23 NPC patients were respectively designed for SMART and CRT, and dose volume histograms (DVH) were employed to evaluate the received doses in the target volumes, parotid and the circumferential normal tissues of both groups. Results The received doses and conformity index (CI) of target volumes in SMART group were higher than those in CRT group, while the received doses of normal tissues including the parotid were
lower than CRT group (P<). Conclusion SMART can reduce the received doses in the normal tissues and increase CI and received average dose of target volumes.
Key words: nasopharyngeal carcinoma; simultaneous modulated accelerated radiotherapy
鼻咽癌目前常规放射治疗所采用的大野照射,腮腺等重要器官均在野内,对正常组织副作用大,限制了病灶总体剂量的提升,局部复发率相对较高,限制了常规放射治疗在临床上的继续发展;而同步加量调强放射治疗(simultaneous modulated accelerated radiotherapy,SMART)技术是在同一个照