文档介绍：M┐AT13抗胃癌的作用机制
作者:李永琦,许才绂,黄裕新,赵国宁,王庆莉
【关键词】胃癌
关键词: 胃癌;医学,中国传统;投药,局部中图号: 文献标识码:A
摘要:目的 M-AT13对裸鼠胃癌荷瘤模型的治疗作用及机制. 方法通过建立裸鼠移植瘤模型与瘤体内局部注射药物,采用大体、组织学、M-AT13,5-FU与华蟾素对移植瘤的治疗效果,M-AT13作用机制. M-AT13具有较强的肿瘤细胞杀伤作用和抑制作用,%,抑瘤效果明显强于5-M-AT13不仅可引起肿瘤组织坏死,抑制细胞增殖,还可增强局部免疫力,促进纤维组织增生. M-AT13具有较强的抗肿瘤效果,有较大的临床应用价值,为临床治疗胃癌提供了新的思路与方法.
Abstract:AIM To investigate the effects and mechanism of pound chinese traditional M-AT13)on xenografted human gastric Nude mice tumor xenograft model,intratumor injection of drugs,histo-logical study,ultrastructural morphological observation,flow cytometric analysis were C
CM-AT13exerted potent cytocidal and cytostatic effects on gas-tric cancer tumor growth inhibiting rate in vivo %,which was markedly higher than that of5-FU and Huachansu M-AT13also enhenced the immune function of nude mice,promoted fibrous tissue hyperplasia,inhibited cell multipolar M-AT13is a potent antitumor drug,the study of its ef-fects and mechanisms may supply a new theoretical basis for the clinical treatment of gastric cancer.
0 引言
胃癌目前仍是严重威胁人民生命健康的恶性肿瘤之一,手术切除率低[1,2] ,大量的临床随机资料结果显示术后放化疗等辅助治疗并不能延长患者的生存期[2-4] ,寻找更有效的治疗胃癌药物和手段,-AT13在体外实验中已证实对人胃癌SGC-7901细胞具有较强的杀伤作用,而对正常血管内皮细胞与平滑肌细胞的杀伤作用较弱[5] .我们通过建立人胃癌SGC-7901细胞裸鼠移植瘤模型[6,7] M-AT13方式,分别从大体、细胞学、M-AT13的抗肿瘤作用与机制.