文档介绍：伤科熏洗方对类风湿性关节炎患者血清肿瘤坏死因子-α和白细胞介素-1β水平的影响
作者:熊鹏程,卢芙蓉,秦铀,沈霖沈霖
【摘要】目的探讨伤科熏洗方对类风湿性关节炎(RA)的疗效及其对RA患者血清肿瘤坏死因子-α(TNF-α)和白细胞介素-1β(IL-1β)水平的调节作用。方法选取110例RA活动期患者,随机分为治疗组和对照组,每组55例。治疗组采用伤科熏洗方联合西药治疗,对照组仅用西药治疗,共4周。观察2组的临床疗效以及治疗前后临床症状和实验室指标的变化,采用ELISA法检测患者血清TNF-α和IL-1β水平。%%,治疗组明显高于对照组(P<)。治疗组和对照组临床症状均明显改善(P<),但治疗组明显优于对照组(P<)。治疗组血沉、C反应蛋白、TNF-α和IL-1β水平均明显降低(P<),对照组无明显变化(P>)。结论伤科熏洗方下调TNF-α和IL-1β可能是其治疗RA的重要机制之一。
【关键词】伤科熏洗方;类风湿性关节炎;肿瘤坏死因子-α;白细胞介素-1β
Abstract:Objective To investigate the efficacy of Shangke Xunxi formula on rheumatoid arthritis (RA) and regulating effects on serum TNF-
α and IL-1β levels in patients with RA. Methods One hundred and ten patients with RA enrolled were randomly divided into treatment group and control group, 55 patients in each group. The treatment group was treated with Shangke Xunxi bined with western medicine for 4 weeks, while the control group only received the treatment of western medicine. Curative effects in the two groups were evaluated after treatment. Syndrome profile and laboratory examinations were observed before and after treatment. Moreover, ELISA were performed to measure serum TNF-α and IL-1β. Results Total effective rate in treatment group (%) was significantly higher than that in control group (%). Clinical syndromes were improved in the two groups (P<), but it was more obvious in treatment group than in control group (P<). ESR, CRP, TNF-α and IL-1β levels were markedly decreased in treatment group (P<), but no obvious change was observed in control group (P>). Conclusion Down-regulation of TNF-α and IL-1β levels with Shangke Xunxi formula might play a key role in its therapy of RA. Key words:Shangke Xunxi formula;rheumatoid arthritis;tumor necrosis factor-α;interleukin-1β
类风湿性关节炎(rheumatoid arthritis,RA)是一种以关节滑膜炎为特征的慢性全身性自身免疫性疾病。滑膜炎持久反复发作,关节内软骨和骨的破坏,导致关节功能障碍,甚至残废[1]。RA发病率高,病机复杂,治愈率低,对该病的治疗学研究一直是国内外药物研究领域的热点[2]。伤科熏洗方是我们在中医辨证论治原则指导下,结合现代药理研究成果,研制开发的用于骨关节疾病