文档介绍：子宫内膜异位症患者血清和腹腔液VEGF测定及其诊断价值
【摘要】目的: 测定子宫内膜异位症(EMT)患者血清和腹腔液VEGF(血管内皮生长因子)水平,并探讨它的诊断价值. 方法: 采用RIA的方法测定34例EMT患者和15例非EMT患者(对照组)血清和腹腔液中VEGF的含量,并与RAFS评分进行相关性分析. 结果: 两组间体质量指数差异均无显著性(P>),EMT组血清VEGF蛋白水平显著高于对照组(ng/L, 463±64 vs 52±30, P<). EMT组腹腔液VEGF极高于对照组(ng/L, 1630±82 vs 142±73, P<). 轻度及重度EMT患者血清和腹腔液VEGF水平均明显高于对照组,重度组又较轻度组明显升高(ng/L,376±59 vs 589±76, P<)和(ng/L, 1201±95 vs 1822±112, P<). EMT患者血清和腹腔VEGF水平与RAFS评分间均呈直线正相关关系. 结论: EMT患者血清和腹腔液VEGF水平明显升高并随疾病的严重程度而上升,尤其是腹腔液VEGF,可能有望成为EMT诊断的辅助性指标.
【关键词】子宫内膜异位症;血管内皮生长因子类;血清;腹液
【Abstract】 AIM: To determine the levels of vascular endothelial growth factor (VEGF) protein in sera and peritoneal fluid from patients with endometriosis (EMT) and to evaluate its diagnostic value. METHODS: The VEGF levels in sera and peritoneal fluid from 34 patients with EMT (experimental group) and 15 cases without EMT (control group) were detected by radio
linked immunoassay (RIA). The correlation between the detection results and RAFS scores was also analyzed. RESULTS: Basal metabolism index (BMI) had no significant difference between the two groups (P>). Sera VEGF level of EMT patients was significantly higher than that of control group [(463±64), (52±30) ng/L respectively, P<]. Peritoneal fluid VEGF level in EMT cases was significantly higher than that in healthy controls [(1630±82), (142±73)ng/L respectivel