文档介绍：非小细胞肺癌免疫指标、癌胚抗原及铁蛋白的相关性分析
作者:叶环,郑加永,施肖红,钱小英,金晓盛
【摘要】目的:研究非小细胞肺癌患者免疫指标、癌胚抗原(CEA)与铁蛋白(SF)之间的关系。方法:回顾性分析92例非小细胞肺癌患者的临床资料,分析患者的CD3+T、CD4+T、CD8+T及CD4+/CD8+、NK细胞、B细胞、CEA和SF变化的关系。结果:①CEA(+)组中,CD4+T、CD4+/CD8+及NK细胞明显降低(P <), CD8+T及SF明显增高(P <)。CEA与CD4+T、CD8+T、CD4+/CD8+及NK细胞水平密切相关(P <)。②SF(+)组中,CD4+T、CD4+/CD8+及NK细胞明显降低(P <), CD8+T明显增高(P <),CD3+T明显增高(P <)。SF与CD4+T、CD8+T、CD4+/CD8+及NK细胞水平密切相关(P <),与CD3+T水平密切相关(P <)。结论:非小细胞肺癌患者存在不同程度的细胞免疫状态紊乱,且与CEA、SF变化密切相关。
【关键词】非小细胞肺癌;免疫;癌胚抗原;血清铁蛋白
Abstract: Objective: To investigate the relationship among immunologic factors,carcinoembryonic antigen (CEA) and serum ferritin (SF) in patients with nonsmall-cell lung cancer. Mothods: Ninty-two patients with nonsmall-cell lung cancer were analyzed retrospectively. The alternation of CD3+T,CD4+T,CD8+T,CD4+/CD8+,NK cell and B cell and their relationship with CEA,SF were observed and analyzed. Results:
① Percentage of CD4+T, NK cell and the ratio of CD4+/CD8+ significantly reduced in CEA (+) group (P <). Percentage of CD8+T and the SF level significantly increased in CEA (+) group (P <). CEA level was significantly correlated to the percentage of CD4+T、 CD8+T, NK cell and the ratio of CD4+/CD8+ (P <). ② Percentage of CD4+T, NK cell and the ratio of CD4+/CD8+ significantly reduced in SF(+)group (P <). Percentage of CD8+T