文档介绍：河北大学
硕士学位论文
可注射性聚N-丙烯酰基甘氨酸的合成及药物释放特征
姓名:李倩
申请学位级别:硕士
专业:高分子化学与物理
指导教师:邓奎林
2011-05
摘要
摘要
本论文的主要内容:合成了 N-丙烯酰基甘氨酸单体,制备了可注射性 pH/温度响应
聚 N-丙烯酰基甘氨酸水凝胶并对其性能进行表征,研究了其药物释放行为;制备了 pH/
温度响应聚(N-丙烯酰基甘氨酸)-壳聚糖水凝胶,讨论了水凝胶的溶胀行为及药物释
放特征。
以甘氨酸、丙烯酸和苯甲酰氯等为原料,合成了 N-丙烯酰基甘氨酸。以 N-丙烯酰
基甘氨酸为单体,用氧化-还原体系过硫酸钾/亚硫酸氢钠作为引发剂,通过自由基聚合
制备出响应性可注射聚 N-丙烯酰基甘氨酸(PNAG)水凝胶。采用红外光谱(IR)与核磁共
振光谱(1H-NMR) 对 PNAG 的结构进行了表征。在不同温度、pH 和 PNAG 浓度下,采
用试管倒置法,测定了 PNAG 水凝胶的凝胶化时间。研究了温度、PNAG 浓度等因素对
水凝胶溶胀行为的影响。以咖啡因作为模型药物,将其包埋在 PNAG 水凝胶中,研究了
其体外释放行为,并探讨了水凝胶的降解特点。
将天然聚合物——壳聚糖引入到水凝胶中,制备了 pH/温度响应性聚(N-丙烯酰基
甘氨酸)-壳聚糖水凝胶,研究了水凝胶在不同温度、不同 pH 值缓冲溶液中溶胀度随时
间的变化规律;以其为药物载体,研究了温度、 pH 值对模型药物咖啡因在体外的药物
释放行为的影响。
关键词可注射水凝胶 pH/温度敏感性药物释放聚( N-丙烯酰基甘氨酸)
溶胀行为
I
Abstract
Abstract
In this work, a novel injectable poly(N-acryloylglycine) (PNAG) hydrogel was
synthesized on base of glycine. The pH/temperature sensitivity and application in drug release
was been studied. Poly(N-acryloylglycine)-chitosan (PNAG-CS) was prepared and it’s
swelling behaviors and drug release profile were also discussed.
In this paper, we synthesized N-acryloylglycine on base of glycine, benzyl chloride and
acrylic. Then the poly(N-acryloylglycine) (PNAG) hydrogel was prepared. The molecular
structures of the corresponding monomer and polymer have been confirmed by FTIR and 1H
NMR measurements. The sol-gel transition behaviors of PNAG in its aqueous solution were
evaluated using test tube-inverting method, as a function of PNAG concentration, pH, and
ionic strength. The swelling behaviors of hydrogel PNAG were systematically investigated at
different temperatures and PNAG concentration. Using caffeine as a model drug, the in vitro
drug release behavior was been researched. In addition, PNAG has showed degradability to
some extent.
By the introduction of natural chitosan, we firstly prepared the pH/temperature sensitive
PNAG-CS hydrogel. The effects of temperature and pH on the swelling behavior of hydrogel
were systematically stu