文档介绍：Studies on Preparation Technology,Quality Standard and
Preliminary pharmacodynamic of Qixian Granules
Speciality: Pharmacy
Author: Li xing-chun
Tutor: Zhang chang-lin
Abstract
Chronic urticaria is mon irritability dermatosis,clinical main performance is
skin appear red or white rash pieces,attack suddenly and no fixed place,itch reckless,also
with happen abdominal pain,diarrhea,even shock,menace people's life and health seriously.
So it is e a task for medical to develop a safe and effective present,can seasonable
eliminate urticaria symptoms,prompt the patient resumed as soon as possible,and can cure
urticaria drugs.
The research is based on definite effect clinical experience to
various kinds of medicinal prescription in patibility of the analysis and major
ponent physicochemical properties of the analysis. Investigated the
prescription of extracting process,pharmaceutical technology,established quality
standards,and made a preliminary pharmacodynamics study.
Used orthogonal test method,ottelia alismoides rate and index concentrations as
evaluation index to investigate influence the factors of herbs extraction,optimizated the
best extraction technology; used qualified percentage of particle size,appearance shape and
rest angle as index to investigated the influence of accessories and other factors for the
optimum proeessing technology,screened best molding process of the formulations,
conducted pilot enlargement test to verify the selected process. The ingredients of
Astragaloside IV and Chlorogenic acid has been carried out by HPLC,and honeysuckle
flower,Scutellaria baicalensis was identified by TLC. Then the research of preliminary
pharmacology experimental was fulfilled on the basis of controllable quality standard. The
granules had satisfactory effect on the model of allergic itchy skin and skin late hairstyle
allergy mice in certain doses.
The standard of the granule