文档介绍：668实用预防医学2008年6月第15卷第3期PracticalPreventiveMedicine,,Vol15,:1006—3110(2008)03—0668—04169例急性白血病免疫表型分析李艳明,曹志红,彭敏源【论著】摘要:目的探讨急性白血病的免疫表型特征,为急性白血病的诊断提供依据。方法收集169例初治急性白血病患者骨髓或外周血标本,采用流式细胞仪对其白血病细胞进行免疫表型分析。结果95例急性髓细胞白血病(acutemyeloblasticleukemia,AML)患者中59例为纯髓系抗原表达,34例伴淋系抗原(CD19、CD7)表达。64例急性淋巴细胞白血病(acutelymphoblasticleukemia)患者中62例表达淋系抗原,纯T系抗原表达8例,纯B系抗原表达44例,6例伴有髓系抗原(CD33)表达;1例ALL—L2为纯髓系(CD33、CD34)表达,1例ALL—L2八个抗原检测均为阴性。10例急性混合型白血病(mixedacuteleukemia,MAL)同时表达两种以上淋系和髓系抗原标志。结论免疫分型能助诊一些特殊类型的白血病(如minimallydifferentiatedacutemydoidleukemia,AMLM0;MAL);免疫分型是对白血病细胞形态学诊断的重要补充。关键词:免疫分型;急性白血病;分化簇;流式细胞仪中图分类号:R557文献标识码:AImmunophenotypeAnalysison169CasesofAcuteLeukemiaLIYanming,CAOZhi—hong,PENGMin—yuan(XiangyaHospital,CentralSouthUniversity,Changsha410008,Hunan)Abstract:-odTheimmunophenotypeofbonemarroworbloodsamplescollectedfrOm169patientswithnewlydiagnosedacuteleuke—-eloidleukemia(AML),34patientswithAMLshowedaberrantlymphoidantigens(CD19orCD7)-genswereexpressedin620f64patientswithacutelymphoidleukemia(ALL),-tientwithALL—L2,only0D33and0D34weredet