文档介绍：2010,44(6):27~29/赵永星,等中国兽药杂志#27#注射用伊维菌素亚微乳的制备及其稳定性研究赵永星,张雪晓,孙倩,赵阳,刘卫晶,陈五常111112(,郑州450001;,河南商丘476312)[收稿日期]2010-03-22[文献标识码]A[文章编号]1002-1280(2010)06-0027-03[中图分类号][摘要]以大豆磷脂S75、注射用大豆油和Poloxamer188为辅料,采用高压匀质法,制备注射用伊维菌素亚微乳。粒度/Zeta电位测定仪测得其粒径、多分散系数和Zeta电位分别为(?)nm、(?)和(-?)mV;加速稳定性试验后,其外观、pH、粒径、电位和药物含量等均符合要求;局部刺激性较普通注射液轻。结果表明,注射用伊维菌素亚微乳制备工艺简单、稳定性好、刺激性小。[关键词]伊维菌素;亚微乳;稳定性;局部刺激性StudiesonPreparationandStabilityofIvermectinSubmicronEmulsionforInjectionZHAOYong-xing,ZHANGXue-xiao,SUNQian,ZHAOYang,LIUWei-jing,CHENWu-chang(,ZhengzhouUniversity,Zhengzhou450001;.,Ltd,Shangqiu,Henan476312;China)111112Abstract:Ivermectinsubmicronemulsionforinjectionwaspreparedbyhigh-pressurehomogeneoustechniqueandsoybeanphospholipidsS75,,polydispersityindexandZetapotentialweremeasuredbyparticlesize/,polydispersityindexandZetapotentialwas(?)nm,(?),and(-?),ttheappearance,pH,particlesize,,