文档介绍：【doc】辛伐他汀和***伐他汀对高胆固醇喂养兔的血管内皮功能的影响辛伐他汀和***伐他汀对高胆固醇喂养兔的血管内皮功能的影响?,7辛伐他汀和***伐他汀对高胆固醇喂养兔的血管内皮功能的影响,/兰金晓峰,张新超(北京医科大学人民医院心内科,北京100044),72,【关?铘】辛伐他汀;***伐他汀i内皮臂倩物作用;鳇固醇,膳食i降血脂药倩理学【摘要】_?:魂察辛伐他汀和***:共28只纯种日本大耳白兔,随机分为4组(每组7只):A组,B组和C组均先喂以15%(质量分数)的高胆固醇饲料4周,%(质量分数)的高胆固醇饲料4周,%(质量分数)的高胆固醇饲料加辛佳他汀5mg'kgI1-dI14周,c组喂以15%(质量分数)的高胆固醇饲料加***伐他汀20rng?kg叫?dI14周,,甘油三酯,,切成4n?n长的血臂环置浴槽中做离体{董流实验,分别观察对乙酰胆碱***?;A组血清胆固醇水平明显升高,,,***;辛伐他汀和***伐他汀均可预防高胆固醇喂养兔的血管内皮功能失调,二者之间无显着性差异.【中圈分类号】-332【文献标识码】A【文章编号】(2000)02—0026—,XUCher~一Bin,JINXiao-—Ch白.(DepamnentofCardiology,People'5Hospital,BeijingMedicalUniversity,Beijing1000441KEYWORDSSimvastatin;Fluvestatin;Endothelium,vascular/drugeff;Cholesterol,dietary;Antilipemicagents/pharmacolAI~lqRACTObjeetive:Toobservetheeffectsofsimvastatinandfluvastatinonvascularendothelialfunctionincholesterol—fedrabbitsMethods:,%%cholesterolchowfor4weeks;groupBreceived15%cholesterolchowandsimvastatin5mg';%'dfor4weeks;~:TotalandLDLcholesterollevelsingroupAwereelevatedaignificantlyanddecreasedingroupBandCIngroupA,endothelium—dependentrelaxationtoacetylcholinewassignificantlyimpairedandcontractiveresponsestonoradrenalineweresignificantlyincrea