文档介绍：
异叶青兰挥发油及四种提取物对两种呼吸
道病毒的体外抑制作用#
文娟1,杨平荣2,李萍2,金赟1,丁家栋1,方媛1,张春江1**
(1. 兰州大学生命科学学院,兰州 730000;
2. 甘肃省医疗器械检验所,兰州 730000)
摘要:目的:探讨藏药异叶青兰四种提取物抗腺病毒(ADV)、流感甲型病毒 A/汉防
/359/95(H3N2) 两种呼吸道病毒的作用。方法:采用细胞病变法(CPE)测定挥发油对细胞
的半数毒性浓度(TC50),及其对病毒的半数效应浓度(EC50),以治疗系数(TI)为指标
评价药效。结果:五种样品对 ADV 的治疗指数为 ~,其中异叶青兰挥发油抗 ADV
活性最高。五种样品对 A/汉防/359/95(H3N2) 的治疗指数为 ~,异叶青兰石油醚
提取物抗 A/汉防/359/95 活性最高。结论:异叶青兰挥发油及四种提取物都具有一定抗 ADV
活性。
关键词:藏药;异叶青兰;腺病毒;流感甲型病毒 A/汉防/359/95(H3N2);抗病毒活性
中图分类号:Q93-31
The Anti-respiroviruses Effort of Esstential Oil and Extracts
from Tibetan Herbal Medicine Dracocephalum
Heterophyllum Benth
WEN Juan1, YANG Pingrong2, LI Ping2, JIN Yun1, DING Jiadong1, FANG Yuan1,
ZHANG Chunjiang1
(1. School of Life Sciences, Lanzhou University, Lanzhou 730000;
2. Gansu Institue of Medical Device Testing, Lanzhou 730000)
Abstract: OBJECTIVE To evaluate the antiviral effect and mechanisms of esstential oi and four
extractssfrom Tibetan herbal medicine Dracocephalum heterophyllum Benth. METHODS The
cytotoxicity and the antiviral effective rate was investigated using cytopathic effect(CPE). The
treatment index (TI) was used to estimate the index of antiviral activity. RESULTS The
therapeutic index of five samples to ADV is to . The esstential oil has the highest value.
The therapeutic index of five samples to A/Hanfang/359/95 is ~, The petroleum ether
ext