凝溶胶蛋白与阿尔茨海默症.doc

文档介绍：
凝溶胶蛋白与阿尔茨海默症#
吉丽娜,华子春*
(南京大学生命科学学院,医药生物技术国家重点实验室,南京 210093)
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摘要:阿尔茨海默症(AD)的病理学特征之一是 AD 患者脑内存在以β-淀粉样肽(Aβ)为主
要成分的老年斑。大量的实验证据表明,以 Aβ为靶目标,清除老年斑有助于提高认知能力,
是目前防治 AD 的一个重要研究方向。凝溶胶蛋白是一种重要的肌动蛋白结合蛋白。目前多
个小组的研究成果显示,凝溶胶蛋白能够与 Aβ相互作用,并且抑制 Aβ积聚形成纤维,也
能够引发 Aβ纤维发生解聚。更重要的是,凝溶胶蛋白能够清除转基因 AD 模型小鼠脑内的
老年斑和降低 Aβ的水平。未来凝溶胶蛋白有可能被应用于 AD 的预防和治疗。
关键词:生物化学与分子生物学;阿尔茨海默症;老年斑;凝溶胶蛋白;β-淀粉样肽
中图分类号:Q51, R74
Gelsolin and Alzheimer's disease
JI Lina, HUA Zichun
(The State Key Lab of Pharmaceutical Biotechnology, College of Life Sciences, Nanjing
University, NanJing 210093)
Abstract: The presence of amyloid plaques is one of the neuropathological features of Alzheimer's
disease (AD). Amyloid plaques consist mainly of beta-amyloid peptide (Aβ). Accumulating
experimental evidence shows that, targeted at Aβ, clearance of amyloid plaque is helpful for
improving recognation ability, and will be an important strategy for the treatmet of AD. Gelsolin
is an important actin-binding protein. Results from several research groups show that gelsolin
inhibits the aggregation of Aβ into fibrils, and also disaggregates the preformed Aβ fibrils. More
importantly, gelsolin reduces amyloid plaques and decreases the level of Aβ in transgenic mouse
models of AD. In the future gelsolin will be possiblely used in the prevention and treatment of
AD.
Keywords: Biochemistry and molecular bi