文档介绍：1
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肿瘤防治
Mar
The. e xpression and prognostic
Notch1在腺样囊性
癌组织中的表达及 impact of Notc h1 in adenoid
其对预后的影响 cystic car cinoma and
the study of pr ognosis
赵●华1/张●凯1,*/江●磊2/汪国文2
( 1. 蚌埠医学院第一附属医院口腔科,安徽●
蚌埠●233000;2. 蚌埠医学院第一附属医院胸心
外科,安徽●蚌埠●233000 )
ZHAO Hua1,ZHANG Kai1,*,JIANG Lei2,WANG Guo-wen2
(1. Department of Stomatology, First Affiliated Hospital of Bengbu
Medical College, Bengbu 233000; 2. Department of Cardiothoracic
Surgery, First Affiliated Hospital of Bengbu Medical College, Bengbu
233000, Anhui, China)
【摘要】目的: 探讨腺样囊性癌(adenoid cystic carcinoma,ACC)组织中Notch1的表达,分析其表达与临床病理资料间的关系及
其对预后的影响。方法:患者及对照组正常口腔小涎腺中Notch1的表达,病例进行随
访,分析Notch1的表达与临床病理资料间的关系及其对预后的影响。结果:% (31/38),而正常
口腔小涎腺阳性率为30% (9/30),及正常口腔小涎腺中的表达差异具有统计学意义(P<)。Notch1的表达与病理分
型、T分期及侵犯相邻组织呈正相关(r =,P=;r =,P=;r =,P=)。单因素分析显示:病理分型、
淋巴结转移、Notch1的表达、T分期、侵犯相邻组织对患者的预后有影响(P<),且Notch1的表达和肿瘤分期是影响患者预后的
独立危险因素。结论:ACC生长缓慢,但易复发且伴远处转移,的发生和发展中起重要作用,在评估其预后方面起
一定作用。
【关键词】 Notch1;腺样囊性癌;预后;免疫组织化学
中图分类号:R735 文献标识码: A 文章编号: 1 004-616X(2013)02-0144-05 doi:1 .1004-
ABSTRACT OBJECTIVE: To investigate the expression of Notch1 in adenoid cystic carcinoma,and analyze
the relationship between its expression with clinicopathologic characteristics and its impact on prognosis. METHODS:
Using immunohistochemistr