文档介绍：13
论著
第 25 卷第 4 期 7 月
Subchronic dermal
乳酸钠对大鼠的
toxicity study of sodium 亚慢性经皮
lactate in rats 毒性试验
林●飞/单●纯/许建霞/吕建军
.. ( 中国食品药品检定研究院,北京● 100050 )
LIN Fei,SHAN Chun,XU Jian-xia,LU Jian-jun
(National Institutes for Food and Drug Control, Beijing
100050, China)
【摘要】目的: 观察大鼠连续经皮给予大剂量乳酸钠后的毒性靶器官及其损害的可逆性。方法:设溶剂对照组和乳酸钠高、
中、低3个剂量组(分别为2 000、1 000和500 mg/kg),实验组大鼠连续经皮涂抹乳酸钠90 d,溶剂对照组给予蒸馏水。于第7周、第
13周和停止染毒后4周,每组剖杀部分大鼠做血液学、生化学、眼科、尿液检测,测量脏器湿重和脏器系数,并进行解剖病理学
观察。结果:染毒第13周各剂量组大鼠血液钠离子、钙离子浓度升高,钾离子、氯离子浓度降低,膀胱腔内存在蛋白样物质聚
集;高剂量组大鼠尿液中蛋白和胆红素浓度升高,比重降低。停止染毒后4周高剂量组大鼠血液钠离子浓度仍然较高。结论:乳
酸钠染毒后大鼠出现电解质轻度紊乱和尿液异常、尿蛋白增加等变化,因此乳酸钠对大鼠具有一定的毒性作用。
【关键词】亚慢性经皮毒性;乳酸钠;大鼠;电解质;尿蛋白
中图分类号: 文献标识码: A 文章编号: 1004-616X(2013)04-0297-05 doi:.1004-
【 ABSTRACT】 OBJECTIVE: To study the subchronic dermal toxicity of sodium lactate in rats,and analyze the
an damage and its reversibility. METHODS:Sodium lactate was given to rats by transdermal administration at
dose of 2 000,1 000 and 500 mg/kg for 90 days. Some rats from each group were sacrificed at 7th ,13 th week and 4 weeks
after recovery,blood count and biochemistry were tested,ophthalmic and urinalysis tests were performed,wet weight of
ans and the coefficient values were determined,and anatomic pathology were observed. RESULTS:With
all treatment doses,K+ ,Cl - decreased and Na+ ,Ca 2+ increased,protein precipit