文档介绍：i中文摘要目的???????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????方法6????ApoE-/-???24?????16-18g????????????HHcy??HHcy????????HHcy??HHcy??????ApoE-/-???????????????????????????????????HHcy???????1??????????8????????0??15m/min?60min/d?????5????2?????????????????????????????????????????-?????????????结果1???ApoE-/-?????????????????????????????????????????????????2????????HHcy?ApoE-/-??????????????????????????????HHcy????HHcy??????ApoE-/-???????????????????????????3?HHcy?ApoE-/-???????????????????????????????????????HHcy??????ApoE-/-???????????????HHcy????????????????结论??????????????????????????????????????????????????????????????????????????????????关键词:???????????????ApoE-/-?? iiAbstract Objective To investigate whether aerobic exercise could decrease hyperhomocysteinemia, lipid levels and increase SOD activities in ApoE-/-mice by treadmill exercise to provide a reference, which will further develop the prevention and treatment of high homocysteine induced atherosclerosis in an effective way. Method 24 Six-week-old female ApoE-/- mice, weighing 16-18g, were randomly divided into three groups: Control group, HHcy group and HHcy?Exercise group. HHcy animal models were fed with a high homocysteine chow ( in water). After 1 week of acclimatization, the HHcy?Exercise group was trained in a motorized rodent treadmill for 8 weeks (speed: 15m/min, slope: 0°, 60min/d, 5d/w). Homocysteine levels and lipid levels in plasma were determined enzymatically by auto-biochemistry analysis system. Superoxide dismutase activities were determined by hydroxylamine assay kit. Results 1. There were not significant differences in body weight, daily drinking amount, and plasma total cholesterol, LDL-c, HDL-c and triglyceride concentrations between the three groups. 2. The level of homocysteine in mice blood in HHcy group were apparently higher than Control group (P=), furthermore, the homoc