文档介绍：肝癌经导管动脉化疗栓塞术的CT灌注成像评价        [08-12-0310:24:00]    编辑:studa20                 作者:陈光斌,邹文远,张自力,石思李,唐先志【摘要】 目的:探讨CT灌注成像对肝细胞癌(HCC)经导管动脉化疗栓塞术(TACE)的临床意义。方法:患者于TACE前1d及术后7~10d行CT灌注扫描,测量肿瘤组织及正常肝组织灌注参数。结果:肿瘤组织TACE术前、术后HBF、HBV、HAP存在显著差异(P<),MTT、PS、HAF、PVP无显著差异(P>)。正常组织TACE术前、术后各灌注参数无显著差异(P>)。结论:CT灌注成像可客观评价TACE前后血供变化,对指导TACE治疗有着重要价值。【关键词】 经导管动脉化疗栓塞术;肝细胞癌;CT灌注成像   Abstract:ObjiectiveToinvestigatethebloodsupplychangesofhepatocellularcarcinoma(HCC)beforeandaftertranscatheterarterialchemoembolization(TACE)putedtomographyperfusionimaging(CTPI).MethodsCTperfusionscanswereperformed1dbeforetreatmentand7~.lesionsandnormaltissuesweremeasured,includingthevaluesofbloodflow(BF),bloodvolume(BV),meantransittime(MTT),permeability(PS),hepaticarterialfraction(HAF),hepaticarterialperfusion(HAP),portalveinperfusion(PVP).ResultsThedifferencesofHBF,HBV,lesionswerestatisticallysignificant,MTT,PS,HAF, CTPImaybeasafeandeffectivemethodstoevaluatethetherapeuticeffect ofTACE.   Keywords:Transcatheterarterialchemoembolization;putedtomographyperfusionimaging   经导管动脉化疗栓塞术(transcatheterarterialchemoembolization,TACE)已成为治疗肝癌非手术疗法的首选[1]。但其5年生存率低于10%,远期疗效不理想,根本原因在于肿瘤血管的形成,使肿瘤得以继续生长、复发和转移,故肝癌TACE前后血流动力学变化目前已成为研究热点。putedtomographyperfusionimaging,CTPI)对肝细胞癌TACE前后血流灌注变化特点进行了初步探讨。   1 材料和方法    一般资料   选择我院