文档介绍：
7 种余甘子树皮化合物体外抗单纯疱疹病毒
1 型活性研究#
马凯琦,陈茂芸,王一飞**
5
10
15
20
25
30
35
(暨南大学生物医药基地,广州 510632)
摘要:目的研究 7 种余甘子树皮的化合物体外抗单纯疱疹病毒 1 型活性。方法采用细胞病
变效应法(Cytopathogenic effect, CPE)测定余甘子树皮的化合物的药物毒性及抗单纯疱疹
病毒 1 型的活性。结果 7 种余甘子树皮的化合物中具有部分抗单纯疱疹病毒 1 型活性的成
分。结论 7 种余甘子树皮的化合物具有抗 HSV-1 的活性,适用于抗单纯疱疹病毒 1 型治疗
药物的深入研究与开发。
关键词:抗病毒;余甘子;单纯疱疹病毒 1 型;细胞病变效应法
中图分类号:
Study on the Anti-HSV-1 Activity of Extract from
Phyllanthus emblica Linn in Vitro
Ma Kaiqi, Chen Maoyun, Wang Yifei
(Jinan Biomedicine Research and Development Center, Jinan University, Guangzhou 510632)
Abstract: IObjective To investigate the anti-herpes simplex virus type1 (HSV-1) activities of 7
extracts from Phyllanthus emblica Linn in vitro. Methods Cytotoxicity and anti-herpes simplex
virus type1 activity of different extracts were determined by cytopathogenic effect assay (CPE).
Results pounds from Phyllanthus emblica Linn showed antiviral activities toward
HSV-1. Conclusion pounds from Phyllanthus emblica Linn have anti-HSV-1 activity in
vitro and can be used for the further research and development of anti-HSV-1 drugs.
Key words: antiviral activity; Phyllanthus emblica Linn; herpes simplex virus type 1;
cytopathogenic effect
0 引言
单纯疱疹病毒 1 型(Herpes simplex virus type 1, HSV-1),为线性双链 DNA
病毒,是疱疹病毒科的典型代表,由于在感染急性期发生水疱疹皮疹即所谓单纯
疱疹而得名[1],广泛存在于自然界中,目前已鉴定的约有 100 种,可引起多种人
类疾病感染。人类是单纯疱疹病毒的唯一自然宿主,其在宿主体内建立潜伏感染,
一定