文档介绍：
基于多级小波域变换的时域扩散荧光层析
成像方法#
李娇1,2,张燕1,赵会娟1,2,张丽敏1,2,高峰1,2**
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(1. 天津大学精密仪器与光电子工程学院,天津 300072;
2. 天津市生物医学检测技术与仪器重点实验室,天津 300072)
摘要:面向基于无限平板荧光扩散解析模型的时域扩散荧光层析成像的反演问题,提出了一
种基于多级小波域变换的图像重建方法。与基于全空间域离散像点的传统重建算法不同,
采用小波函数对未知参量的空间域进行多尺度分解,通过逐级细化分解尺度来减少重建的
未知参量个数,从而有效地改善重建过程的病态性,提高图像的量化度和空间分辨率。仿
体实验验证中采用了基于时间相关单光子技术的非接触模式时域测量系统和两个双目标体
平板仿体。实验结果证明了所提的图像重建方法可以有效地改善荧光参数重建图像的空间分
辨率,而且相较于传统算法其重建图像量化度有着显著地提高。
关键词:时域扩散荧光层析;离散小波变换;逆问题;多尺度分解;非接触测量模型
中图分类号:R-331
A Method for Time-Domain Diffuse Fluorescence
Tomography Based on Multi-Level Wavelet Transform
Li Jiao1,2, Zhang yan1, Zhao Huijuan1,2, Zhang Limin1,2, Gao Feng1,2
(1. College of Precision Instruments and Optoelectronics Engineering, Tianjin University, Tianjin
300072, China;
2. Tianjin Key Laboratory of Biomedical Detecting Techniques and Instruments, Tianjin 300072,
China)
Abstract: A multi-level scheme for time-domain diffuse fluorescence tomography in transmission
mode of a slab turbid geometry has been proposed based on discrete wavelet transform, to reach
different resolution levels of wavelet domain position and in some degree to reduce the
number of unknown parameters at coarse resolution levels and alleviate the ill-posedness of
inverse problem. Time-resolved data for experimental validation of the proposed scheme is based
on non-contact mode for time-correlated single-pho