文档介绍：ISBN: 0-8247-0294-8
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In memory of my parents,
for their love and guidance
Preface
ic toxicology studies have been used to assess mutagenicity of environ-
mental, pharmaceutical, and agricultural chemicals for over 30 years. Most of the
activities in this field have been focused on the development of new test methods,
standardization of test procedures, generation of mutagen databases, and cross-
validation of test results. After many years of continual evaluations and refine-
ments, contemporary routine ic toxicology tests are reliable tools for the de-
tection of environmental mutagens.
Since ic damage to humans can cause serious conditions such as birth
defects and cancers, identifying mutagens and carcinogens and minimizing their
risks to humans are obvious goals for the protection of public health. When expo-
sure is unavoidable, an accurate estimation of human risk as a result of exposure
is essential for making regulatory decisions.
Quantitative cancer risk assessment is an intricate process that utilizes
knowledge from many diff