文档介绍：2005年第25卷有机化学Vol. 25, 2005第2期, 197~200 Chinese Journal anic Chemistry No. 2, 197~200 * E-mail: liming928@ Received May 10, 2004; revised July 22, 2004; accepted September 13, 2004. 山东省自然科学基金(No. Y2003B01)和国家自然科学基金(No. 20172031)资助项目. ·研究论文·2-(1-苯基/取代苯基-3-甲基-5-氯-1H-4-吡唑基)-3-芳酰胺-4-噻唑啉酮的合成及生物活性文丽荣a李明*,a,b景淑霞a曹玮a杨华铮*,b(a青岛科技大学化学与分子工程学院青岛 266042) (b南开大学元素有机化学国家重点实验室天津 300071) 摘要利用1-芳基-3-甲基-5-氯-1H-4-吡唑醛(2)分别与取代苯甲酰肼反应, 进一步与巯基乙酸关环, 合成了11个新的2-(1-芳基-3-甲基-5-氯-1H-4-吡唑基)-3-芳酰胺-4-噻唑啉酮类化合物 3a~3k, 并利用元素分析, IR, 1H NMR和X-ray晶体衍射确定了其结构. 初步生物活性表明: 3e具有杀菌活性, 3e和3k具有除草活性. 关键词吡唑衍生物; 噻唑啉酮; 合成; 生物活性Synthesis and Biological Activities of 2-(1-Aryl-3-methyl-5-chloro- 1H-pyrazol-4-yl)-3-(1-aroylamino)-4-thiazolidinones WEN, Li-Ronga LI, Ming*,a,b JING, Shu-Xiaa CAO, Weia YANG, Hua-Zheng*,b(a College of Chemical and Molecular Technology, Qingdao University of Science and Technology, Qingdao 266042)(b Institute of anic Chemistry, Nankai University, Tianjin 300071)Abstract By the reactions of 1-aryl-3-methyl-5-chloro-1H-4-pyrazolylformaldehydes (2) with aroylhydra-zines and followed by the addition of mercaptoacetic acid, eleven pounds 2-(1-aryl-3-methyl-5- chloro-1H-pyrazol-4-yl)-3-(1-aroylamino)-4-thiazolidinones 3a~3k have been synthesized. Their structures were characterized by elemental analysis, IR and 1H NMR spectra, and one of them 3d by X-raydiffraction study. The preliminary