文档介绍：~20062IJ双氢青蒿素哌喹片治疗云南省恶性疟的临床观察[论着]孙晓东’,张再兴,刘德全,黄国珍,邓艳,张苍林,王声亮,李红斌,黄梅,蒋迎春,赵来发,肖育江摘要:,%,平均退热时间(±)h;平均无性体原虫转阴时间(±)h;%,,速效,低毒,疗程短,服药依从性高,:双氢青蒿素哌喹片;2d4次疗法;恶性疟;云南省中图分类号:R382,31文献标识码:A文章嫡号:1009—9727(2Oo6)O2—2l1一O2Clinicalstudyontheefficacyofdihyroartemisininandpiperaquineintreatmentofmulti——dong,ZHANGZai—xing,LIUDe—quart,eta1.(YunnanProvincialInstituteofParasiticDiseases,Simao665000,Yunnan,)Abstract:Objec~veToobservetheeffectandsafetyofDihydroartemisininPiperaquinePhosphateTablets(DPPT),whocamefromtheendemicareasofdrugresis—tantfalciparummalariaontheborderofYunnanProvince,weretreatedwith4dosagesofDPPTin2daysandthenfollowed—%,norecrudescencewasobserved,themeanfeversubsidencetimewas(±)h,themeanclearancetimeofasexualparasitesinbloodwas(±)h,%,,quickacting,lowtoxicity,shortcourse,:DihydroartcmisininPiperaquinePhosphateTablets,Treatmentwith4dosagesin2days,Falciparummalaria,Yun-,速效,低毒等优点_l-,为云南抗疟药物政策提供依据,于2002—2004年选择云南边境抗药性恶性疟流行区t3,,镜检无性体原虫密度≥500/t~l血;年龄5—6O岁,2周内未服用过抗疟药物或有抗疟作用的药物如四环素,磺胺类等;志愿参加并签订治疗知情书,,(男4O例,女29例),平均年龄为(±)岁(≤14组21例,>14组48例),1年内有疟史者4H4例(%),无性体原虫几何平均密度为10630(139892508)个/血,配子体携带9例(%),配子体几何平均密度(范围)为92(