文档介绍：· 830 ·系统性红斑狼疮患儿肿瘤坏死因子-α、抗ds-(江苏苏州215600);(江西南昌330006)摘要:目的探讨系统性红斑狼疮(SLE)及狼疮性肾炎(LN)患儿血清肿瘤坏死因子-α(TNF-α)、抗ds-DNA抗体水平的变化及其与病情的相关性。方法选择67例SLE患儿(其中52例为LN患儿),以30例健康体检儿童为对照组,采用酶联免疫吸附法检测血清TNF-α水平,放射免疫法检测抗ds-DNA抗体水平。结果SLE和LN患儿的血清TNF-α、抗ds-DNA抗体水平均高于对照组,差异均有统计学意义(P均<);SLE和LN患儿中活动期患儿的血清TNF-α、抗ds-DNA抗体水平均高于静止期患儿,差异均有统计学意义(P均<);67例SLE患儿TNF-α与SLE疾病活动指数、抗ds-DNA水平均呈明显正相关(P<)。结论SLE及LN患儿血清TNF-α、抗ds-DNA抗体水平升高,且与病情活动性相关。[ 临床儿科杂志,2013,31(9):830-832]关键词:系统性红斑狼疮;狼疮性肾炎;肿瘤坏死因子-α;抗ds-DNA抗体中图分类号:R725文献标志码:A文章编号:1000-3606(2013)09-0830-03Study on the levels of tumor necrosis factor-α and anti-ds-DNA antibody in children with systemic lupus erythe-matosus HU Dan, LIU Yang, LIU Yanling (1. Department of Pediatrics, Zhangjiagang Hospital Affiliated to Soochow Uni-versity, Suzhou 215600, Jiangsu, China; 2. Department of Pediatrics, The Second Affiliated Hospital of Nanchang University, Nanchang 330006, Jiangxi, China)Abstract: Objectives To investigate the changes and significance of serum tumor necrosis factor-α(TNF-α) and anti-ds-DNA antibody in systemic lupus erythematosus (SLE) and lupus nephritis (LN) in children. Methods Sixty-seven children with SLE among whom 52 children had LN were selected and 30 healthy children were selected as normal controls. The level of serum TNF-α was measu