文档介绍：ic Polymorphisms Related to Testosterone
Metabolism in Intellectually Gifted Boys
Peter Celec1,2,3*, Denisa Tretina´rova´ 3, Gabriel Mina´rik1,3,4, Andrej Ficek3,4, Toma´sˇ Szemes3,
Silvia Lakatosˇova´ 5, Eva Schmidtova´ 5,Ja´n Turnˇ a3,L9udevı´tKa´dasˇi3,4, Daniela Ostatnı´kova´ 5
1 Institute of Molecular Biomedicine, Comenius University, Bratislava, Slovak Republic, 2 Institute of Pathophysiology, Comenius University, Bratislava, Slovak Republic,
3 Department of Molecular Biology, Comenius University, Bratislava, Slovak Republic, 4 Institute of Molecular Physiology and ics, Slovak Academy of Sciences,
Bratislava, Slovak Republic, 5 Institute of Physiology, Comenius University, Bratislava, Slovak Republic
Abstract
Prepubertal testosterone levels are lower in intellectually gifted boys. The aim of this pilot study was to analyze potential
ic factors related to testosterone metabolism in control and gifted boys. Intellectually gifted (; n = 95) and
control (n = 67) boys were genotyped. Polymorphisms of interests were chosen in genes including androgen and estrogen
receptors, 5-alpha reductase, aromatase and sex hormone binding globulin. Significant differences between control and
gifted boys in genotype distributions were found for ESR2 (rs928554) and SHBG (rs1799941). A significantly lower number of
CAG repeats in the AR gene were found in gifted boys.