文档介绍：THE JOURNAL OF BIOLOGICAL CHEMISTRY Vol. 279, No. 30, Issue of July 23, pp. 31131–31138, 2004
© 2004 by The American Society for Biochemistry and Molecular Biology, Inc. Printed in .
Appropriate Function of 11-Hydroxysteroid Dehydrogenase
Type 1 in the Endoplasmic Reticulum Lumen Is Dependent on
Its N-terminal Region Sharing Similar Topological
Determinants with 50-kDa Esterase*
Received for publication, December 15, 2003, and in revised form, April 28, 2004
Published, JBC Papers in Press, May 19, 2004, DOI
Christoph Frick‡, Atanas G. Atanasov‡, Peter Arnold‡, Juris Ozols§, and Alex Odermatt‡¶
From the ‡Division of Nephrology and Hypertension, Department of Clinical Research, University of Berne,
3010 Berne, Switzerland and the §Biochemistry Department, University of Connecticut Health Center,
Farmington, Connecticut 06030
By interconverting glucocorticoids, 11-hydroxy- In humans, 11-HSD11 catalyzes the reduction of biologi-
steroid dehydrogenase type 1 (11-HSD1) exerts an im- cally inactive cortisone to active cortisol, thereby playing an
portant pre-receptor function and is currently consid- essential role in the local activation of the glucocorticoid recep-
ered a promising therapeutic target. In addition, 11- tor. Recent animal experiments provided insight into the
HSD1 plays a potential role in 7-ketocholesterol patho