文档介绍：振源胶囊治疗慢性心力衰竭有效性比较的Meta分析曹野,王伟琼,卢力,郭小梅"(华屮科技大学同济医学院附属同济医院心内科,湖北武汉430000)[摘要]计算机检索PubMed>EMbasc、,搜集振源胶囊联合常规西药治疗(试验组)与单纯西药治疗(对照组)比较治疗慢性心力衰竭的相关随机对照试验(RCT),检索时间限制为从建库至2016年10月。由两位评价者独立筛选文献、提取资料和评价纳入文献的偏倚风险后,,系统评价振源胶囊对慢性心力衰竭病人疗效。最终纳入14个RCT,共1204例慢性心力衰竭患者。Meta分析结果显示,试验组的心功能疗效[RR=,95%CI(,),P<]、LVEF变化】WMD=,95%CI(,),P<]、BNP变化],95%C:I(-,-),P=]、心输出量[WMD=,95%CI(,),P<]>每搏输出量[WMD=,95%CI(,),]、HAMA评分[WMD=・,95%CI(-,-),P<]、HAMA心理疗效[RR=,95%CI(,),P=]>中医症候疗效[RR=,95%CI(,),P<0・00001]均显著高于对照组,且差异具有统计学意义。现有证据表明,振源胶囊联合常规西药治疗可以改善慢性心力衰竭病人心功能,心理状态,提高生活质量,且安全性好。受纳入研究质量和数量的限制,仍需大规模高质量RCT予以验证。[关键词]振源胶囊;慢性心力衰竭;心功能;Meta分析;系统评价;随机对照试验EectsofZhenyuanCapsuleontheCardiacFunctionofPatientswithChronicHeartFailure:AMeta-analysisCAOYe,WANGWei-qiong,LULi,GUOXiao-mei*(DepartmentofCardiology,TongjiHospital,TongjiMedicalCollege,HuazhongUniversity-ofScienceandTechnology^Wuhan430030,China)[Abstract]TosystematicallyreviewtheeffectsofZhenyuancapsuleonimprovingthecardiacfunctionofpatientswithchronicheartfailure,DatabasesincludingMEDLINE,EMbase,TheCochraneLibrary,KI,VIPandWanFangDataweresearchedelectronicallyfrominceptiontoJuly2016tocollectrandomizedcontrolledtrials(RCTs)aboutZhenyuancapsuleforchronicheartfailure・Tworeviewersindependentlyscreenedliteratures,,Meta-・Atotalof14RCTsinvolving1204patientswereincluded•TheresultsofMeta-analysisshowedthattheZhenyuancapsulegrouphadsignificantlybettereffectivenessofcardiacfunction(RR=,95%,P<),changesofLVEF(WMD=,95%,P<),changesofBNP(,95%CI・-^=),cardiacoutput(WMD=0.&95%,P<),strokevolume(WMD=,95%<),scoreofHAMA(,95%CI-・<),psychologi