文档介绍：Tumor-Suppressing
Viruses, Genes,
and Drugs
This Page Intentionally Left Blank
Tumor-Suppressing
Viruses, Genes,
and Drugs
Innovative Cancer
Therapy Approaches
Edited by
Hiroshi Maruta
Ludwig Institute for Cancer Research
Royal Melbourne Hospital
Parkville/Melbourne, Australia
ACADEMIC PRESS
A Harcourt Science and pany
San Diego San Francisco New York
Boston London Sydney Tokyo
Contents
Contributors xi
Preface xv
1 Oncolytic Viruses: Virotherapy for Cancer 1
Lynda K. Hawkins and David Kirn
I. Introduction 2
II. Attributes of Replication-Selective Viruses for
Cancer Treatment 4
III. Approaches to Optimizing Tumor-Selective
Viral Replication 4
IV. Adenoviruses 5
V. Poliovirus 7
VI. Vesicular Stomatitis Virus 8
VII. Reovirus 8
VIII. Bacteria 9
IX. inia Virus 10
X. Herpesvirus 12
XI. Clinical Trial Results with petent
Adenoviruses in Cancer Patients 16
XII. Results from Clinical Trials with dl1520
(Onyx-015, or CI-1042) 18
XIII. Future Directions: Approaches to Improving the
Efficacy of Replication-Selective Viral Agents 23
XIV. Summary 24
References 24
2 Reovirus Therapy of Ras-Associated Cancers 31
Patrick W. K. Lee
I. Introduction 31
II. Reovirus Oncolysis 34
III. Concluding Remarks 40
References 41
v
vi Contents
3 Oncolytic Herpes Simplex Virus (G207) Therapy:
From Basic to Clinical 45
Tomoki Todo, Michael I. Ebright, Yuman Fong, and
Samuel D. Rabkin
I. Introduction 45
II. Preclinical Studies of G207 48
III. G207 Clinical Trial 65
IV. Conclusions 67
References 68
4 p53 and Its Targets 77
Rishu Takimoto and Wafik S. El-Deiry
I. Introduction 77
II. Activation of p53 78
III. Downstream Mediators of p53 81
References 90
5 Prospects for Tumor Suppressor Gene Therapy:
RB as an Example 97
Daniel J. Riley and Wen-Hwa Lee
I. Introduction 97
II. Functions of RB 100
III. esses with RB Gene Therapy 110
IV. Perspectives 113
References 115
6 CDK Inhibitors