文档介绍：苦参素联合拉米夫定治疗乙肝早期肝硬化的临床疗效宋健,钟慧闽,朱寿美,姚萍,杨杰,中国人民解放军第401医院消化内科,山东省青岛市266071)宋健,男,1967-12-08生,汉族,河南淮阳县人,2005年第二军医大学消化专业博士,副主任医师,主要从事消化系疾病的内镜诊治及慢性肝病的防治研究。项冃负责人:钟慧闽,266071山东省青岛市,解放军第401医院消化内科,E-mail:bella@电话:0532-83970047收稿日期:传真:0532-接受Fl期:binedwithlamivudineontheearlycirrhosisafterchronichepatitisB・JianSong,Hui-minZhong,Shou-meiZhu,PingYao,JieYang・DepartmentofGanstroenterology,,Qingdao266071,ShandongProvience,:,DepartmentofGanstroenterology,,Qingdao266071,ShandongProvience,・mail:******@Received: accepted:AbstractObjective:binedwithlamivudineontheearlycirrhosisafterchronichepatitisB-Methods:Randomlyselect65patientswiththeearlycirrhosisafterchronichepatitisB,33patientsreceivedoxymatrineandlamivudine(Oxymatrinecapsule200mgpotid,LamivudinelOOmgpoqdfor1year),32patientswereconsideredasthecontrolgroupmerelyreceivedlamivudine(lOOmgpoqdfor1year).Liverfunction,thevaluesofserumliverfibrosismarkerincludingprecollagentypeIII(PCIII),hyaluroniaacid(HA),laminin(LN),collagentypeIV(IV-C)andthequantitationofHBV-DNAat0,3,6,and12monthsweredetected-Onthesametime,ScoreofChild-:Liverfunction()andScoreofChild-,HA,LN,andIV-(P<).ThequantitationofHBV-DNAinthealliancegroupat6and12monthswasdecreasedsignificantlythanthecontrol5s(P<).Theliverbiopsypathologicalchangessuchasnecrosisoflivercellandinfiltrationofinflammationcellinportalareaswaslessenedobviouslyaftertreatment12months()・Conclusions:oxymatrinenotonlycanimproveliverfunction,lesseninflammationandenhanceanti-virusofhepatitisBbutalsocanpalliateordelayprogressioninearlycirrhosisafterchronichepatitisB•Keywords:Oxymatrine;Lamivudine;HepatitisB;CirrhosisSongJ,ZhongHM,ZhuSM,YaoP,