文档介绍：
10: Carboxylic
Acids and
Derivatives
CH3 CHCHCHCHCO2H
山梨酸
O
O H
geranyl formate(甲酸香叶酯)
O isoamyl butyrate(丁酸异戊酯)
O
H CO2CH3
dimethyl fumarate(霉克星)
CH3O2C H
OCH3
H
NHCH2 OH 辣椒素
H
O
CON(C2H5)2
DEET
CH3
OH H
CO2H
glycinoeclepin A
O CO H
O 2
CHCH2
OH
O Vernolepin
O CH2 抗肿瘤药
CH2 O
O
N(CH )
H3C OH H 3 2
OH
CONH
OH 2
OHOOOH
四环素: R = R' : H
土霉素: R : H, R' : OH
金霉素: R , Cl, R' : H
O
Me Me
Me erythromycin
HO OH 红霉素
Me Me
O
H5C2 Me
O
O Me
O NMe2
Me O
OMe
Me O
HO OH
Me
王浆酸
O
HCO2H 9-ODA
H
OH
HCO2H
9-HDA
H
The Importance of Carboxylic Acids
(RCO2H)
• Starting materials for acyl
derivatives (esters, amides, and
acid chlorides)
• Abundant in nature from
oxidation of aldehydesand
alcohols in metabolism
Naming Carboxylic
Acids and Derivatives
• If derived from open-chain alkanes,
replace the terminal -e of the alkane
name with -oicacid
• The carboxyl carbon atom is C(1)
Alternative Names:
• Compounds with ¾CO2H bonded to
a ring are named using the suffix -
carboxylic acid
• mon names for formic acid
(HCOOH) and acetic acid (CH3COOH)