文档介绍：胸腔内联合灌注博莱霉素和恩格菲治疗恶性胸腔积液的疗效评价作者:沈四新,江晓肖,方鹏,陈达伟,陈少明【摘要】目的探讨胸腔内联合灌注博莱霉索和恩格菲治疗恶性胸腔积液的临床疗效及毒副反应。方法经病理确诊的恶性胸腔积液49例,胸腔置管引流术排尽胸液后,随机分为两组,治疗组(A组25例),在胸腔内灌注博莱霉素45恩格菲3000U,对照组(B组24例)在胸腔内灌注博莱霉素45mg,1周后重复1次,观察疗效、生活质量及毒副反应。结果A组完全缓解(CR)12例,部分缓解(PR)9例,总有效率84%;B组完全缓解(CR)6例,部分缓解(PR)7例,总有效率54%,两者比较差异有显著性()oKarnokky评分&gt;70分治疗组较对照组有显著提高(P<)o毒副反应:A组有发热6例(24%),胸痛4例(16%),恶心2例(%),B组有发热5例(21%),胸痛3例(13%),恶心2例(%),两组比较差异无显著性(P>)o结论胸腔内联合灌注博莱霉素和恩格菲是一种有效、副反应小、可耐受的方法。【关键词】恶性胸腔积液;博莱霉素:恩格菲;灌注TreatmentofMaiignantPleuralEffusionUsingDIeomysinandEnGeFeiIntrapleurallyInfusionAbstract: ,bleomysin45mg+EnGeFei3000Uwereinfusionedintopleuralcavityintherapygroup(groupA),andbleomysin45mgingroup(groupB)・thetreatmentwasrepeatedafteraweekandobservedtheefficacy,toxicltiesandqualityoflifeforfourweeks・ResultsTheoverallresponseratewas84%ingroupAand54%ingroupTherewasstatisticaldifferenceintwogroup(/0・05).TheKarnofskyscoreishigeringroupAthanIngroupB・Thesystemictoxicitywasmild,ineludingfever(24%),pleuriticpain(16%),nansea(8・0%)ingroupAandfever(21%),pleuriticplain(13%),nansea(%)(P&gt;).ConclusionThetreatmenttousebleomysinandEnGeFeithroughthoracictubeisregardedaseffective,hodformalignantp