文档介绍：江苏大学硕士学位论文摘要本论文系统地研究了肺气肿胶囊的制备工艺、质量标准及稳定性试验。主要研究内容和结果如下: 。优选辅料及其用量,并以制粒的干燥条件、干燥时间、颗粒的吸湿性等因素作为指标进行了考察,研究了制剂的制备方法。选择微粉硅胶为辅料,%,以5%聚丙烯酸乙醇溶液为润湿剂,采用湿法制粒,填充胶囊。所得胶囊美观,质量可控。中试结果表明该工艺合理可行,产品质量可控。。建立了野马追中槲皮素、山柰素定性定量分析方法。槲皮素、山柰素的TLC定性分析方法:以甲苯一乙酸乙酯一甲酸(9:3:1)为展开剂,硅胶G薄层板,显色剂为1%---***化铝乙醇液。结果槲皮素&=,山奈素Rf=。HPLC定量分析方法:色谱柱为Kromasil- C18柱,%磷酸(60:40),检测波长为370nm,柱温为300C, ,方法灵敏度高,重现性好,结果准确。。制剂中***羊藿、牡荆油、丹参、补骨脂、黄芪采用薄层色谱法进行定性鉴别,方法灵敏度高,专属性强,重现性好。采用高效液相色谱法对主要成分***羊藿苷及复方中化学药盐酸克伦特罗进行了定量分析。***羊藿苷HPLC定量分析条件为:, %磷酸(55:45),检测波长为270nm,柱温为350C,流速为 ,方法灵敏度高,专属性强,重现性好,结果准确。。考察结果为本品性状、鉴别、检查、含量测定、卫生学检查均符合指标,说明本品质量稳定。关键词:512艺研究质量标准野马追***羊藿苷槲皮素山柰素江苏大学硕上学位论文 ABSTRACT A systematical study on thepreparation techniques,quality standard,stability testofFeiqizhong capsules was main contexts and conclusions were 嬲following: optimize thetypeanddosage of additive agents,the mono—factor design tests was used,and ation time,condition andgrain’S moisture absorption were alsoexamined,the preparation process was optimal conditions are asfollow:the capsules weremanufacturedby wetgranulation with5% polypropylene acidethanol solution was used tOmix themicromeritics silicagel and drug powder inthepartition of :1,and theouterside ofcapsules arepolished and thequality resultsofmiddle scale experiment showed thatthe preparation isoperationable reliabllyand thequality ofcapsules iscontrollable. totherelating references,the quality standards ofherba Eupatorii was Was used to identify the main gradients ofquercetin and kamepferol inherba Eupatorii:the silicagel thinlayerplate andthedeveloping agent consisting of amixture oftoluene—ethyl acetate·ethylacid(9:3:1)wereused,and the allunim trichloricide·ethanol solution Was used to react relativeflow value ofquercetin ,and thevalue ofka